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Literature summary for 1.4.3.1 extracted from
- Effects of D-aspartate treatment on D-aspartate oxidase, superoxide dismutase, and caspase 3 activities in frog (Rana esculenta) tissues (2010), Chem. Biodivers., 7, 1459-1466.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| peroxisome | - |
Pelophylax lessonae | 5777 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-aspartate + H2O + O2 | Pelophylax lessonae | - |
oxaloacetate + NH3 + H2O2 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pelophylax lessonae | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Pelophylax lessonae | - |
| heart | - |
Pelophylax lessonae | - |
| kidney | - |
Pelophylax lessonae | - |
| liver | - |
Pelophylax lessonae | - |
| testis | - |
Pelophylax lessonae | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-aspartate + H2O + O2 | - |
Pelophylax lessonae | oxaloacetate + NH3 + H2O2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| D-AspO | - |
Pelophylax lessonae |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Pelophylax lessonae | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Pelophylax lessonae | chronic D-Asp treatment leads to upregulation of D-AspO expression in all tissues, along with up- or downregulation of superoxide dismutase 1 and caspase 3 depending on the tissues, overview. D-Asp treated kidney showed the highest D-AspO activity | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | in frog tissue, D-AspO plays an essential role in modulating the D-Asp concentration, exaggerated D-Asp concentrations activate SOD1 as cytoprotective mechanism in the kidney, whereas, in the brain and in the heart, where the antioxidant action of SOD1 is limited, caspase 3 is activated, overview | Pelophylax lessonae |
| physiological function | in frog tissue, D-AspO plays an essential role in modulating the D-Asp concentration. Induction of oxidative stress following D-Asp exposure is primarily related to its metabolism by inducible D-AspO | Pelophylax lessonae |
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Release 2023.1 (January 2023)
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