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Literature summary for 1.4.1.B5 extracted from

  • Umair, S.; Bland, R.J.; Simpson, H.V.
    Glutamate synthase, but not GABA shunt enzymes, contributes to nitrogen metabolism of the sheep abomasal nematode parasites Haemonchus contortus and Teladorsagia circumcincta (2011), Exp. Parasitol., 127, 9-13.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
NH4Cl activates Teladorsagia circumcincta

Inhibitors

Inhibitors Comment Organism Structure
azaserine strong inhibition Haemonchus contortus
azaserine strong inhibition Teladorsagia circumcincta

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.6
-
2-oxoglutarate pH 7.5, 30°C, L3 stage enzyme Teladorsagia circumcincta
0.6
-
L-glutamine pH 7.5, 30°C, L3 stage enzyme Teladorsagia circumcincta
0.8
-
2-oxoglutarate pH 7.5, 30°C, adult worm enzyme Teladorsagia circumcincta
0.9
-
2-oxoglutarate pH 7.5, 30°C Haemonchus contortus
1
-
L-glutamine pH 7.5, 30°C Haemonchus contortus
1.5
-
L-glutamine pH 7.5, 30°C, adult worm enzyme Teladorsagia circumcincta

Metals/Ions

Metals/Ions Comment Organism Structure
NH4Cl activates Haemonchus contortus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 L-glutamate + NAD+ Haemonchus contortus
-
L-glutamine + 2-oxoglutarate + NADH + H+
-
r
2 L-glutamate + NAD+ Teladorsagia circumcincta
-
L-glutamine + 2-oxoglutarate + NADH + H+
-
r
2 L-glutamate + NADP+ Haemonchus contortus
-
L-glutamine + 2-oxoglutarate + NADPH + H+
-
r
2 L-glutamate + NADP+ Teladorsagia circumcincta
-
L-glutamine + 2-oxoglutarate + NADPH + H+
-
r

Organism

Organism UniProt Comment Textmining
Haemonchus contortus
-
-
-
Teladorsagia circumcincta
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
larva L3 stage Teladorsagia circumcincta
-
additional information no activity in L3 stage Haemonchus contortus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.024 0.041 pH 7.5, 30°C, L3 stage Teladorsagia circumcincta
0.033 0.059 pH 7.5, 30°C, adult worm Haemonchus contortus
0.051 0.095 pH 7.5, 30°C, adult worm Teladorsagia circumcincta

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 L-glutamate + NAD+
-
Haemonchus contortus L-glutamine + 2-oxoglutarate + NADH + H+
-
r
2 L-glutamate + NAD+
-
Teladorsagia circumcincta L-glutamine + 2-oxoglutarate + NADH + H+
-
r
2 L-glutamate + NADP+
-
Haemonchus contortus L-glutamine + 2-oxoglutarate + NADPH + H+
-
r
2 L-glutamate + NADP+
-
Teladorsagia circumcincta L-glutamine + 2-oxoglutarate + NADPH + H+
-
r

Synonyms

Synonyms Comment Organism
GOGAT
-
Haemonchus contortus
GOGAT
-
Teladorsagia circumcincta

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Haemonchus contortus
30
-
assay at Teladorsagia circumcincta

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
Haemonchus contortus
7.5
-
-
Teladorsagia circumcincta

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Haemonchus contortus
NAD+
-
Teladorsagia circumcincta
NADH
-
Haemonchus contortus
NADH
-
Teladorsagia circumcincta
NADP+
-
Haemonchus contortus
NADP+
-
Teladorsagia circumcincta
NADPH
-
Haemonchus contortus
NADPH
-
Teladorsagia circumcincta