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Literature summary for 1.4.1.4 extracted from
- Redox engineering by ectopic expression of glutamate dehydrogenase genes links NADPH availability and NADH oxidation with cold growth in Saccharomyces cerevisiae (2015), Microb. Cell Fact., 14, 100 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | P07262 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GDH1 | - |
Saccharomyces cerevisiae |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | a high-copy number of the GDH2-encoded NADH-specific glutamate dehydrogenase gene stimulates growth at 15°C, while overexpression of NADPH-specific GDH1 has detrimental effects. Cells overexpressing GDH1 still display a cold-sensitive phenotype in presence of tryptophan or nictotinic acid in the medium. Total cellular NAD levels are a limiting factor for growth at low temperature in Saccharomyces cerevisiae | Saccharomyces cerevisiae |
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