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Literature summary for 1.4.1.4 extracted from

  • Pamula, F.; Wheldrake, J.F.
    Purification and properties of the NADP-dependent glutamate dehydrogenase from Dictyostelium discoideum (1991), Mol. Cell. Biochem., 105, 85-92.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
ADP at 1 mM, 11% activation Dictyostelium discoideum
GTP at 0.083 mM 22% activation Dictyostelium discoideum

Inhibitors

Inhibitors Comment Organism Structure
AMP slight inhibitory Dictyostelium discoideum
p-hydroxymercuribenzoic acid at 0.08 mM, 50% inhibition Dictyostelium discoideum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0097
-
NADPH reductive amination Dictyostelium discoideum
1.2
-
2-oxoglutarate reductive amination Dictyostelium discoideum
2.2
-
NH4+ reductive amination Dictyostelium discoideum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
52000
-
alpha6, 6 * 52000, SDS-PAGE Dictyostelium discoideum
294000
-
gel filtration Dictyostelium discoideum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutamate + NADP+ + H2O Dictyostelium discoideum
-
2-oxoglutarate + NADPH + NH3
-
r

Organism

Organism UniProt Comment Textmining
Dictyostelium discoideum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Dictyostelium discoideum

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
121
-
reductive amination at 30°C Dictyostelium discoideum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxoglutarate + NH4+ + NADPH
-
Dictyostelium discoideum L-glutamate + NADP+
-
?
L-glutamate + NADP+ + H2O
-
Dictyostelium discoideum 2-oxoglutarate + NADPH + NH3
-
r

Subunits

Subunits Comment Organism
homohexamer alpha6, 6 * 52000, SDS-PAGE Dictyostelium discoideum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
reductive amination Dictyostelium discoideum

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Dictyostelium discoideum
NADPH
-
Dictyostelium discoideum