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Literature summary for 1.4.1.2 extracted from

  • Gallant, J.L.; Viljoen, A.J.; van Helden, P.D.; Wiid, I.J.
    Glutamate dehydrogenase is required by Mycobacterium bovis BCG for resistance to cellular stress (2016), PLoS ONE, 11, e0147706 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis variant bovis
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General Information

General Information Comment Organism
physiological function presence of GDH is required for the utilization of glutamate as a major carbon source and to sustain Mycobacterium bovis BCG during infection of both murine RAW 264.7 and bone-marrow derived and macrophages. Inactivation of Gdh increases sensitivity to low pH stress and nitrosative stress Mycobacterium tuberculosis variant bovis