Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) pLysS cells | Porphyromonas gingivalis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2E,6S)-6-aminohept-2-enedioic acid | - |
Porphyromonas gingivalis | |
(2S)-2-amino-6-methylideneheptanedioic acid | - |
Porphyromonas gingivalis | |
(3S)-3-amino-4-{[(1S)-1-carboxy-2-phenylethyl]amino}-4-oxobutanoic acid | 2% inhibition at 3 mM | Porphyromonas gingivalis | |
(5S)-5-[(2S)-2-amino-2-carboxyethyl]-4,5-dihydro-1,2-oxazole-3-carboxylic acid | - |
Porphyromonas gingivalis | |
2-[(3S,4S)-3-carboxy-4-propylpyrrolidin-1-yl]-6-methylpyridine-3-carboxylic acid | - |
Porphyromonas gingivalis | |
3-([3-[(4-methoxybenzene-1-sulfonyl)amino]quinoxalin-2-yl]amino)benzoic acid | - |
Porphyromonas gingivalis | |
3-([4-[(3,4-dimethylbenzene-1-sulfonyl)amino]-1-hydroxynaphthalen-2-yl]sulfanyl)propanoic acid | - |
Porphyromonas gingivalis | |
4-oxo-4-[4-[(quinoxalin-2-yl)sulfamoyl]anilino]butanoic acid | - |
Porphyromonas gingivalis | |
5-carboxy-2,2-dihydroxypentanoate | 13% inhibition at 3 mM | Porphyromonas gingivalis | |
5-[(3-carboxyphenyl)sulfamoyl]-2-hydroxybenzoic acid | 6% inhibition at 3 mM | Porphyromonas gingivalis | |
N-[3-[(benzenesulfonyl)amino]phenyl]-3,5-dimethyl-1H-pyrazole-4-sulfonamide | 17% inhibition at 3 mM | Porphyromonas gingivalis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.06 | - |
NADP+ | at pH 10.5 and 25°C | Porphyromonas gingivalis | |
0.37 | - |
meso-2,6-diaminoheptanedioate | at pH 10.5 and 25°C | Porphyromonas gingivalis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
meso-2,6-diaminoheptanedioate + H2O + NADP+ | Porphyromonas gingivalis | - |
L-2-amino-6-oxoheptanedioate + NH3 + NADPH + H+ | - |
? | |
meso-2,6-diaminoheptanedioate + H2O + NADP+ | Porphyromonas gingivalis W83 | - |
L-2-amino-6-oxoheptanedioate + NH3 + NADPH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Porphyromonas gingivalis | Q7MW40 | - |
- |
Porphyromonas gingivalis W83 | Q7MW40 | - |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA column chromatography | Porphyromonas gingivalis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
meso-2,6-diaminoheptanedioate + H2O + NADP+ | - |
Porphyromonas gingivalis | L-2-amino-6-oxoheptanedioate + NH3 + NADPH + H+ | - |
? | |
meso-2,6-diaminoheptanedioate + H2O + NADP+ | - |
Porphyromonas gingivalis W83 | L-2-amino-6-oxoheptanedioate + NH3 + NADPH + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 32000, SDS-PAGE | Porphyromonas gingivalis |
Synonyms | Comment | Organism |
---|---|---|
DDH | - |
Porphyromonas gingivalis |
meso-2,6-diaminopimelate dehydrogenase | - |
Porphyromonas gingivalis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Porphyromonas gingivalis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.157 | - |
at pH 10.5 and 25°C | Porphyromonas gingivalis | 3-([3-[(4-methoxybenzene-1-sulfonyl)amino]quinoxalin-2-yl]amino)benzoic acid | |
0.31 | - |
at pH 10.5 and 25°C | Porphyromonas gingivalis | 3-([4-[(3,4-dimethylbenzene-1-sulfonyl)amino]-1-hydroxynaphthalen-2-yl]sulfanyl)propanoic acid | |
0.356 | - |
at pH 10.5 and 25°C | Porphyromonas gingivalis | 4-oxo-4-[4-[(quinoxalin-2-yl)sulfamoyl]anilino]butanoic acid | |
1.164 | - |
at pH 10.5 and 25°C | Porphyromonas gingivalis | 2-[(3S,4S)-3-carboxy-4-propylpyrrolidin-1-yl]-6-methylpyridine-3-carboxylic acid |