Activating Compound | Comment | Organism | Structure |
---|---|---|---|
DTT | 31% activation at 10 mM | Thielaviopsis paradoxa | |
glutathione | 16.5% activation at 10 mM | Thielaviopsis paradoxa |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Co2+ | 17% inhibition at 10 mM, 23.75% at 20 mM | Thielaviopsis paradoxa | |
iodoacetate | 23.75% inhibition at 10 mM | Thielaviopsis paradoxa | |
Zn2+ | 57% inhibition at 10 mM, 72.75% at 20 mM | Thielaviopsis paradoxa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.197 | - |
NADH | pH 8.5, 60°C | Thielaviopsis paradoxa | |
0.274 | - |
NAD+ | pH 9.5, 60°C | Thielaviopsis paradoxa | |
1.35 | - |
L-alanine | pH 9.5, 60°C | Thielaviopsis paradoxa | |
3 | 3.5 | NH3 | pH 8.5, 60°C | Thielaviopsis paradoxa | |
8.16 | - |
pyruvate | pH 8.5, 60°C | Thielaviopsis paradoxa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
DL-alanine + H2O + NAD+ | Thielaviopsis paradoxa | - |
pyruvate + NH3 + NADH + H+ | - |
r | |
glycine + H2O + NAD+ | Thielaviopsis paradoxa | - |
glyoxylate + NH3 + NADH + H+ | - |
r | |
L-alanine + H2O + NAD+ | Thielaviopsis paradoxa | - |
pyruvate + NH3 + NADH + H+ | - |
r | |
L-isoleucine + H2O + NAD+ | Thielaviopsis paradoxa | - |
2-oxo-3-methylpentanoate + NH3 + NADH + H+ | - |
r | |
L-serine + H2O + NAD+ | Thielaviopsis paradoxa | - |
3-hydroxypyruvate + NH3 + NADH + NH3 + NADH + H+ | - |
r | |
L-threonine + H2O + NAD+ | Thielaviopsis paradoxa | - |
3-hydroxy-2-oxobutyrate + NH3 + NADH + H+ | - |
r | |
additional information | Thielaviopsis paradoxa | substrate specifiicty, overview. The enzyme is also active with substrates DL-alanine, L-serine, L-isoleucine, L-threonine, and glycine, with L-serine giving the highest activity rate | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Thielaviopsis paradoxa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
native enzyme | Thielaviopsis paradoxa |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DL-alanine + H2O + NAD+ | - |
Thielaviopsis paradoxa | pyruvate + NH3 + NADH + H+ | - |
r | |
glycine + H2O + NAD+ | - |
Thielaviopsis paradoxa | glyoxylate + NH3 + NADH + H+ | - |
r | |
L-alanine + H2O + NAD+ | - |
Thielaviopsis paradoxa | pyruvate + NH3 + NADH + H+ | - |
r | |
L-isoleucine + H2O + NAD+ | - |
Thielaviopsis paradoxa | 2-oxo-3-methylpentanoate + NH3 + NADH + H+ | - |
r | |
L-serine + H2O + NAD+ | - |
Thielaviopsis paradoxa | 3-hydroxypyruvate + NH3 + NADH + NH3 + NADH + H+ | - |
r | |
L-threonine + H2O + NAD+ | - |
Thielaviopsis paradoxa | 3-hydroxy-2-oxobutyrate + NH3 + NADH + H+ | - |
r | |
additional information | substrate specifiicty, overview. The enzyme is also active with substrates DL-alanine, L-serine, L-isoleucine, L-threonine, and glycine, with L-serine giving the highest activity rate | Thielaviopsis paradoxa | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ALADH | - |
Thielaviopsis paradoxa |
L-alanine dehydrogenase | - |
Thielaviopsis paradoxa |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
60 | - |
assay at | Thielaviopsis paradoxa |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
amination of pyruuvate | Thielaviopsis paradoxa |
9.5 | - |
deamination of L-alanine | Thielaviopsis paradoxa |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Thielaviopsis paradoxa | |
NADH | - |
Thielaviopsis paradoxa |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme plays an important role in the carbon and nitrogen metabolism of microorganisms, it iis a key factor in assimilation of L-Ala as energy source through TCA cycle | Thielaviopsis paradoxa |