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Literature summary for 1.4.1.1 extracted from

  • Berberich, Robert; Kaback, Michael; Freese, Ernst.
    D-Amino acids as inducers of L-alanine dehydrogenase in Bacillus subtilis (1968), J. Biol. Chem., 243, 1008-1013.
No PubMed abstract available

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-Ala + H2O + NAD+ Bacillus subtilis the physiological role is to catabolize L-Ala to pyruvate and NH3, inducible by L-Ala, D-Ala and 11 other D-amino acids. The enzyme catabolizes L-Ala, and thereby limits the amount of L-Ala available to alanine racemase for the synthesis of D-Ala pyruvate + NH3 + NADH
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Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Ala + H2O + NAD+
-
Bacillus subtilis pyruvate + NH3 + NADH
-
r
L-Ala + H2O + NAD+ the physiological role is to catabolize L-Ala to pyruvate and NH3, inducible by L-Ala, D-Ala and 11 other D-amino acids. The enzyme catabolizes L-Ala, and thereby limits the amount of L-Ala available to alanine racemase for the synthesis of D-Ala Bacillus subtilis pyruvate + NH3 + NADH
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Bacillus subtilis
NADH
-
Bacillus subtilis