Activating Compound | Comment | Organism | Structure |
---|---|---|---|
testosterone | 5alpha-reductase activity in males is increased by testosterone regardless of breeding season, thus, testosterone appears to regulate its own metabolism in male, but not female, anoles | Anolis carolinensis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-dihydrotestosterone + NADP+ | Anolis carolinensis | 5alpha-reductase converts testosterone to 5alpha-dihydrotestosterone | testosterone + NADPH + H+ | - |
r | |
5alpha-pregn-3,20-dione + NADP+ | Anolis carolinensis | 5alpha-reductase also can act on progesterone, which is metabolized to an intermediate product that is then converted to allopregnanolone | progesterone + NADPH + H+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Anolis carolinensis | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | enzyme activity in both sexes | Anolis carolinensis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-dihydrotestosterone + NADP+ | - |
Anolis carolinensis | testosterone + NADPH + H+ | - |
r | |
5alpha-dihydrotestosterone + NADP+ | 5alpha-reductase converts testosterone to 5alpha-dihydrotestosterone | Anolis carolinensis | testosterone + NADPH + H+ | - |
r | |
5alpha-pregn-3,20-dione + NADP+ | - |
Anolis carolinensis | progesterone + NADPH + H+ | - |
r | |
5alpha-pregn-3,20-dione + NADP+ | 5alpha-reductase also can act on progesterone, which is metabolized to an intermediate product that is then converted to allopregnanolone | Anolis carolinensis | progesterone + NADPH + H+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
5alpha-reductase | - |
Anolis carolinensis |
General Information | Comment | Organism |
---|---|---|
physiological function | the type I enzyme is important for catabolism of excess steroids, while the type II enzyme has some role in male sexual behavior, whereas no evidence exists for it influencing female receptivity in this species. But 5alpha-reductase may play a role in regulating the effects of progesterone on female reproductive behavior. Females may have lower levels of type II than males | Anolis carolinensis |