Literature summary for 1.3.99.5 extracted from

Paz-y-Min, C.; Witte, T.; Robles, P.; Llumipanta, W.; Diaz, M.; Arevalo, M.
Association among polymorphisms in the steroid 5alpha-reductase type II (SRD5A2) gene, prostate cancer risk, and pathologic characteristics of prostate tumors in an Ecuadorian population (2009), Cancer Genet. Cytogenet., 189, 71-76.

Search for more literature for 1.3.99.5

Cloned(Commentary)

Cloned (Comment)	Organism
gene SRD5A2, genotyping of 114 prostate cancer patients and 144 healthy control males for single-nucleotide polymorphisms, A49T and V89L, overview. Individuals with LL genotype show reduction in the progression to a higher tumor stage	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
A49T	naturally occuring mutation, the mutation is associated with a higher pTNM stage and and elevated Gleason grade. The allelic frequencies of the A49T variant, with 33% controls and 45% prostate cancer cases, are the highest reported worldwide. The polymorphism influences the risk of developing prostate cancer	Homo sapiens
V89L	naturally occuring mutation. The polymorphism influences the risk of developing prostate cancer	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P31213	gene SRD5A2; Ecuadorian population, gene SRD5A2	-

Synonyms

Synonyms	Comment	Organism
5alpha-reductase type II	-	Homo sapiens

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Release 2023.1 (January 2023)