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Literature summary for 1.3.99.5 extracted from

  • Farkash, Y.; Soreq, H.; Orly, J.
    Biosynthesis of catalytically active rat testosterone 5alpha-reductase in microinjected Xenopus oocytes: evidence for tissue-specific differences in translatable mRNA (1988), Proc. Natl. Acad. Sci. USA, 85, 5824-5828.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
Xenopus oocytes are able to synthesize the enzyme, directly by microinjected poly(A)+ RNA prepared from female and male rat liver Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Rattus norvegicus 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
testosterone + reduced acceptor Rattus norvegicus enzyme plays a key role in androgen-dependent target tissues, where it catalyzes the conversion of testosterone to the biologically active dihydrotestosterone, transcriptional control of 5alpha-reductase expression 5alpha-dihydrotestosterone + acceptor
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
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Source Tissue

Source Tissue Comment Organism Textmining
liver activity in female liver is about 4times higher than in male liver Rattus norvegicus
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prostate gland very low activity Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
testosterone + reduced acceptor testosterone i.e. 17beta-hydroxyandrost-4-en-3-one Rattus norvegicus 5alpha-dihydrotestosterone + acceptor
-
 ?
testosterone + reduced acceptor enzyme plays a key role in androgen-dependent target tissues, where it catalyzes the conversion of testosterone to the biologically active dihydrotestosterone, transcriptional control of 5alpha-reductase expression Rattus norvegicus 5alpha-dihydrotestosterone + acceptor
-
 ?