Literature summary for 1.3.99.1 extracted from

Rutter, J.; Winge, D.R.; Schiffman, J.D.
Succinate dehydrogenase - Assembly, regulation and role in human disease (2010), Mitochondrion, 10, 393-401.

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Organism

Organism	UniProt	Comment	Textmining

General Information

General Information	Comment	Organism
additional information	the catalytic core Sdh1 and Sdh2 subunits contain the redox cofactors that participate in electron transfer to ubiquinone. Sdh1 contains the covalently bound FAD cofactor and the binding site for succinate. Sdh2 contains the three Fe-S centers that mediate electron transfer to ubiquinone in the complex of succinate-ubiquinone dehydrogenase, EC 1.3.5.1, regulation of SDH, overview. The Leigh syndrome, also known as subacute necrotizing encephalomyelopathy, is an early-onset progressive neurodegenerative disorder, associated with impaired SDH activity due to mutations, e.g. G555E, mechanism of the disease, overview. Mutations in SDHB,-C, and -D are asscoiated with tumor formation, overview	Homo sapiens

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Release 2023.1 (January 2023)