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Literature summary for 1.3.98.1 extracted from

  • Loffler, M.; Klein, A.; Hayek-Ouassini, M.; Knecht, W.; Konrad, L.
    Dihydroorotate dehydrogenase mRNA and protein expression analysis in normal and drug-resistant cells (2004), Nucleosides Nucleotides Nucleic Acids, 23, 1281-1285.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
leflunomide cell line A20R resistant to leflunomide shows enhanced expression of enzyme to bypass the inhibitory effect, following long-time exposure, enzyme gene amplification can be assumed Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
lymphocyte cell line A20R generated by gradually exposing A20N cells to increasing concentrations of enzyme inhibitor leflunomide Mus musculus
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