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Literature summary for 1.3.8.9 extracted from

  • Zhang, Y.; Bharathi, S.S.; Rardin, M.J.; Uppala, R.; Verdin, E.; Gibson, B.W.; Goetzman, E.S.
    SIRT3 and SIRT5 regulate the enzyme activity and cardiolipin binding of very long-chain acyl-CoA dehydrogenase (2015), PLoS ONE, 10, e0122297.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.8.9

Activating Compound

Activating Compound Comment Organism Structure
additional information SIRT3 deacetylates and SIRT5 desuccinylates K299 which serves to stabilize the essential FAD cofactor in the active site of the enzyme Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial membrane
-
 Homo sapiens 31966
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P49748
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is a cardiolipin-binding protein Homo sapiens ?
-
 ?
palmitoyl-CoA + electron-transfer flavoprotein
-
 Homo sapiens (2E)-2-hexadecenoyl-CoA + reduced electron-transfer flavoprotein
-
 ?

Synonyms

Synonyms Comment Organism
very long-chain acyl-CoA dehydrogenase
-
 Homo sapiens
VLCAD
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Homo sapiens