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Literature summary for 1.3.8.8 extracted from

  • Maher, A.C.; Mohsen, A.W.; Vockley, J.; Tarnopolsky, M.A.
    Low expression of long-chain acyl-CoA dehydrogenase in human skeletal muscle (2010), Mol. Genet. Metab., 100, 163-167.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.8.8

Cloned(Commentary)

Cloned (Comment) Organism
LCAD real-time RT-PCR expression analysis in different tissues Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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 Homo sapiens 5739
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2,6-dimethylheptanoyl-CoA + oxidized flavin Homo sapiens specific LCAD substrate 2,3-dehydro-2,6-dimethylheptanoyl-CoA + reduced flavin
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
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Source Tissue

Source Tissue Comment Organism Textmining
heart very low enzyme content Homo sapiens
-
liver very low enzyme content Homo sapiens
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additional information LCAD real-time RT-PCR expression analysis in different tissues Homo sapiens
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skeletal muscle vastus lateralis, LCAD content compared to that of very-long chain acyl-CoA dehydrogenase, VLCAD, and medium chain acyl-CoA dehydrogenase, MCAD. mRNA presence of LCAD in human skeletal muscle is significantly less than VLCAD and MCAD, LCAD protein is almost undetectable, overview Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,6-dimethylheptanoyl-CoA + oxidized flavin specific LCAD substrate Homo sapiens 2,3-dehydro-2,6-dimethylheptanoyl-CoA + reduced flavin
-
 ?

Synonyms

Synonyms Comment Organism
LCAD
-
 Homo sapiens
long-chain acyl-CoA dehydrogenase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
flavin a flavoenzyme Homo sapiens

General Information

General Information Comment Organism
physiological function long-chain acyl-CoA dehydrogenase is a mitochondrial flavoenzyme that plays no role in long-chain fatty acid beta-oxidation in heart, liver, and skeletal muscle, overview Homo sapiens