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Literature summary for 1.3.8.4 extracted from

  • Mohsen, A.W.; Vockley, J.
    Kinetic and spectral properties of isovaleryl-CoA dehydrogenase and interaction with ligands (2015), Biochimie, 108, 108-119 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.8.4

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Protein Variants

Protein Variants Comment Organism
Y166F mutation does not block enzyme interaction with the electron transfer protein Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
RYATLPNIMKAK twelvemer peptide representing the electron transfer protein docking peptide, ETF betaArg191-betaLys202, competitively inhibits the enzyme reaction when electron transfer protein is used as the electron acceptor Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.001
-
 isovaleryl-CoA pH 8.0, 30°C, calculated per monomer Homo sapiens
0.002
-
 electron transfer protein pH 8.0, 30°C, calculated per monomer Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P26440
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isovaleryl-CoA + electron transfer protein acceptor porcine electron transfer protein Homo sapiens 3-methylcrotonoyl-CoA + reduced electron transfer protein
-
 ?

Synonyms

Synonyms Comment Organism
IVD
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.5
-
 RYATLPNIMKAK pH 8.0, 30°C Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
4300
-
 isovaleryl-CoA pH 8.0, 30°C, calculated per monomer Homo sapiens