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Literature summary for 1.3.8.1 extracted from

  • Goetzman, E.S.; He, M.; Nguyen, T.V.; Vockley, J
    Functional analysis of acyl-CoA dehydrogenase catalytic residue mutants using surface plasmon resonance and circular dichroism (2006), Mol. Genet. Metab., 87, 233-242.
    View publication on PubMed
Search for more literature for 1.3.8.1

Application

Application Comment Organism
additional information development of a novel surface plasmon resonance assay to measure substrate binding Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli XL1 Blue Homo sapiens

Protein Variants

Protein Variants Comment Organism
E368G is unable to form a charge-transfer complex with substrate/product, does not efficiently compete with the wild-type enzyme for the physiological electron acceptor Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
isovaleryl-CoA dehydrogenase E254G inhibits wild-type SCAD Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
by chromatography and fractionation, to ca. 95% homogeneity Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
butyryl-CoA + oxidized acceptor
-
 Homo sapiens crotonyl-CoA + reduced acceptor
-
 ?
crotonyl-CoA + reduced acceptor
-
 Homo sapiens butyryl-CoA + oxidized acceptor
-
 ?

Synonyms

Synonyms Comment Organism
SCAD
-
 Homo sapiens
short-chain acyl-CoA dehydrogenase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Homo sapiens