Protein Variants | Comment | Organism |
---|---|---|
additional information | insertional inactivation of pcyA is not possible in wild-type Synechococcus sp. strain PCC 7002 due to lethality of the mutant, but in a variant heterologously expressing HY2 from Arabidopsis thaliana encoding a phytochromobilin:ferredoxin oxidoreductase | Synechococcus sp. |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
biliverdin Ixalpha + reduced ferredoxin | Synechococcus sp. | - |
(3Z)-phycocyanobilin + oxidized ferredoxin | - |
? | |
biliverdin Ixalpha + reduced ferredoxin | Synechococcus sp. PCC 7335 | - |
(3Z)-phycocyanobilin + oxidized ferredoxin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Synechococcus sp. | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
biliverdin Ixalpha + reduced ferredoxin | - |
Synechococcus sp. | (3Z)-phycocyanobilin + oxidized ferredoxin | - |
? | |
biliverdin Ixalpha + reduced ferredoxin | phycocyanobilin:ferredoxin oxidoreductase uses four electrons from reduced ferredoxin to synthesize phycocyanobilin by regiospecific reduction of the exo vinyl group of ring D and the endo vinyl group of ring A of biliverdin IXalpha | Synechococcus sp. | (3Z)-phycocyanobilin + oxidized ferredoxin | - |
? | |
biliverdin Ixalpha + reduced ferredoxin | - |
Synechococcus sp. PCC 7335 | (3Z)-phycocyanobilin + oxidized ferredoxin | - |
? | |
biliverdin Ixalpha + reduced ferredoxin | phycocyanobilin:ferredoxin oxidoreductase uses four electrons from reduced ferredoxin to synthesize phycocyanobilin by regiospecific reduction of the exo vinyl group of ring D and the endo vinyl group of ring A of biliverdin IXalpha | Synechococcus sp. PCC 7335 | (3Z)-phycocyanobilin + oxidized ferredoxin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PCB:ferredoxin oxidoreductase | - |
Synechococcus sp. |
PcyA | - |
Synechococcus sp. |
phycocyanobilin synthase | - |
Synechococcus sp. |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
Ferredoxin | - |
Synechococcus sp. |
General Information | Comment | Organism |
---|---|---|
evolution | synthesis of linear tetrapyrrole chromophores in cyanobacteria, algae, and plants, ooverview | Synechococcus sp. |
malfunction | because PcyA and PebA, EC 1.3.7.6/1.3.7.3, utilize the same substrate, biliverdin IXalpha, severe overexpression of pebA can limit the availability of phycocyanobilin, which appears to be required for viability when cells are grown in continuous light | Synechococcus sp. |
physiological function | the pcyA gene of Synechococcus sp. strain PCC 7002 is essential | Synechococcus sp. |