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Literature summary for 1.3.5.2 extracted from

  • Schaefer, C.h.M.; Schaefer, M.K.; Loefflerr, M.
    Region-specific distribution of dihydroorotate dehydrogenase in the rat central nervous system points to pyrimidine de novo synthesis in neurons (2010), Nucleosides Nucleotides Nucleic Acids, 29, 476-481.
    View publication on PubMed
Search for more literature for 1.3.5.2

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
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brain presence of enzymatically active DHODH in many regions of the central nervous system, albeit at different intensities. High levels of both DHODH activity and immunoreactivity are observed in the neocortex, hippocampus, spinal cord and choroid plexus. Lower levels are seen in the cerebellum, and only marginal expression in brain stem Rattus norvegicus
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brain stem very low enzyme level Rattus norvegicus
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brain stem very low level both of expression and activity Rattus norvegicus
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central nervous system regiospecific distribution of DHODH, immunohistochemic analysis, overview Rattus norvegicus
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cerebellum low enzyme level Rattus norvegicus
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cerebellum low level both of expression and activity Rattus norvegicus
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cerebral cortex high enzyme level Rattus norvegicus
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choroid plexus high level both of expression and activity Rattus norvegicus
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hippocampus high enzyme level Rattus norvegicus
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hippocampus high level both of expression and activity Rattus norvegicus
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neocortex high level both of expression and activity Rattus norvegicus
-
neuron
-
 Rattus norvegicus
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spinal cord high level both of expression and activity Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
DHODH
-
 Rattus norvegicus

General Information

General Information Comment Organism
metabolism DHODH is the fourth enzyme in the biosynthesis of pyrimidines Rattus norvegicus