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Literature summary for 1.3.5.2 extracted from

  • Hail, N.; Chen, P.; Kepa, J.J.; Bushman, L.R.; Shearn, C.
    Dihydroorotate dehydrogenase is required for N-(4-hydroxyphenyl)retinamide-induced reactive oxygen species production and apoptosis (2010), Free Radic. Biol. Med., 49, 109-116.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.5.2

Cloned(Commentary)

Cloned (Comment) Organism
expression of GFP-tagged enzyme in SW480 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
teriflunomide a redox-silent coenzyme Q antagonist of DHODH Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial inner membrane
-
 Homo sapiens 5743
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-dihydroorotate + FMN Homo sapiens
-
 orotate + FMNH2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
COLO-16 cell
-
 Homo sapiens
-
HaCaT cell premalignant Homo sapiens
-
keratinocyte
-
 Homo sapiens
-
additional information no activity in colorectal carcinoma cells Homo sapiens
-
prostate epithelium DHODH protein is expressed in premalignant and malignant prostate epithelial cells Homo sapiens
-
PWR-1E cell
-
 Homo sapiens
-
skin DHODH protein is expressed in premalignant and malignant skin cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-dihydroorotate + FMN
-
 Homo sapiens orotate + FMNH2
-
 ?

Synonyms

Synonyms Comment Organism
DHODH
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FMN
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens suppression of enzyme expression by siRNA of DHODH down

General Information

General Information Comment Organism
physiological function dihydroorotate dehydrogenase is associated with mitochondrial electron transport and required for de novo pyrimidine synthesis, and is required for N-(4-hydroxyphenyl)retinamide-induced reactive oxygen species production and apoptosis. Chemical inhibition of DHODH activity or the reduction of DHODH protein suppresses 4HPR-induced ROS production and apoptosis in transformed skin and prostate epithelial cells, overview Homo sapiens