Any feedback?
Literature summary for 1.3.5.2 extracted from
- Hydrogen bonding pathways in human dihydroorotate dehydrogenase (2006), J. Phys. Chem. B, 110, 19704-19710.
Application
| Application | Comment | Organism |
|---|---|---|
| additional information | three types of hydrogen bonding pathways, hydrogen bonding of the active base serine to a water molecule, which is hydrogen bonded to the substrate carboxylate group or a threonine residue, the threonine residue is positioned to enable proton transfer to another water molecule leading to the bulk solvent | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| S215C | increase of the average donor-acceptor distances for proton and hydride transfer and disruption of the hydrogen bonding pathways observed for the wild-type enzyme, significant decrease in enzyme activity | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q02127 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dihydroorotate + acceptor | - |
Homo sapiens | orotate + reduced acceptor | - |
? |  |
| additional information | computational method to investigate potential proton relay pathways in the active site of the enzyme | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DHOD | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| flavin | - |
Homo sapiens | |
| FMN | Lys100 and Lys225 enhance the structural stability of the active site by hydrogen bonding to the FMN cofactor | Homo sapiens | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
