Inhibitors | Comment | Organism | Structure |
---|---|---|---|
atovaquone | competitive to quinone | Homo sapiens | |
atovaquone | competitive to quinone | Rattus norvegicus | |
dichloroallyl-lawsone | competitive to quinone | Homo sapiens | |
dichloroallyl-lawsone | competitive to quinone | Rattus norvegicus | |
Lapachol | - |
Homo sapiens | |
Lapachol | - |
Rattus norvegicus | |
Lawsone | - |
Homo sapiens | |
Lawsone | - |
Rattus norvegicus | |
additional information | kinetics of inhibition | Homo sapiens | |
additional information | kinetics of inhibition | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
recombinant protein | - |
Rattus norvegicus | - |
recombinant protein | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dihydroorotate + acceptor | acceptor (low activity): 1,4-naphthoquinone, 5,8-hydroxy-naphthoquinone, juglon, plumbagin, polyporic acid | Homo sapiens | orotate + reduced acceptor | - |
? | |
dihydroorotate + acceptor | acceptor (low activity): 1,4-naphthoquinone, 5,8-hydroxy-naphthoquinone, juglon, plumbagin, polyporic acid | Rattus norvegicus | orotate + reduced acceptor | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00001 | - |
dichloro-allyllawsone | - |
Rattus norvegicus | |
0.000061 | - |
Lapachol | - |
Rattus norvegicus | |
0.000067 | - |
dichloro-allyllawsone | - |
Homo sapiens | |
0.000618 | - |
Lapachol | - |
Homo sapiens | |
0.000698 | - |
atovaquone | - |
Rattus norvegicus | |
0.015 | - |
atovaquone | - |
Homo sapiens | |
0.049 | - |
Lawsone | - |
Rattus norvegicus | |
0.5 | - |
Lawsone | - |
Homo sapiens |