Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.5.2 extracted from

  • Bruneau, J.M.; Yea, C.M.; Spinella-Jaegle, S.; Fudali, C.; Woodward, K.; Robson, P.A.; Sautes, C.; Westwood, R.; Kuo, E.A.; Williamson, R.A.; Ruuth, E.
    Purification of human dihydro-orotate dehydrogenase and its inhibition by A77 1726, the active metabolite of leflunomide (1998), Biochem. J., 336, 299-303.
No PubMed abstract available

Application

Application Comment Organism
medicine enzyme inhibition is a mechanism of action that may be relevant for the therapeutic effects of leflunomide Homo sapiens
medicine great interest in inhibitors as potential therapeutic agents for the treatment of diseases involving aberrant cell proliferation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-hydroxyethylidene-cyanoacetic acid 4-trifluoromethyl anilide anti-proliferative effect of A77 1726 is mediated by inhibition of enzyme Homo sapiens
A77 1726 active metabolite of leflunomide Homo sapiens
brequinar sodium more active than A77 1726 and HR325 Homo sapiens
HR325 structural analogue of A77 1726 Homo sapiens
leflunomide
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
43000
-
x * 43000, SDS-PAGE Homo sapiens
43000
-
? * 43000 Homo sapiens
130000
-
gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens
-
U937 membranes
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens
ion-exchange, hydroxyapatite, gel filtration for U937, cation-exchange for spleen Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
spleen
-
Homo sapiens
-
U-937 cell promyelomonocytic, histiocytic Homo sapiens
-

Storage Stability

Storage Stability Organism
-80°C Homo sapiens

Subunits

Subunits Comment Organism
? x * 43000, SDS-PAGE Homo sapiens
? ? * 43000 Homo sapiens

Synonyms

Synonyms Comment Organism
DHO-DH
-
Homo sapiens