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Literature summary for 1.3.5.1 extracted from
- Old mice present increased levels of succinate dehydrogenase activity and lower vulnerability to dyskinetic effects of 3-nitropropionic acid (2009), Pharmacol. Biochem. Behav., 91, 327-332.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-nitropropionic acid | this study compares the effects of 3-nitropropionic acid in young and old mice. Treatment with 3-nitropropionic acid induces OD in young mice. Old mice present an increase in the basal level of orofacial movement that is not potentiated by any dose of 3-nitropropionic acid. Histochemical analyses show that old mice present an increase in the SDH activity. 3-Nitropropionic acid induces a decrease in SDH activity at both ages | Mus musculus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinate + oxidized donor | endogenous SDH activity results in blue diphormazan deposits from the nitroblue tetrazolium reduction through succinate oxidation | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SDH | - |
Mus musculus |
| succinate dehydrogenase | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Mus musculus |
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Release 2023.1 (January 2023)
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