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Literature summary for 1.3.5.1 extracted from
- A ketogenic diet increases succinic dehydrogenase activity in aging cardiomyocytes (2009), Ann. N. Y. Acad. Sci., 1171, 377-384.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| medium-chain triglycerides ketogenic diet | cytochemical investigation of SDH activity in cardiomyocytes of late adult rats fed for 8 weeks with a medium-chain triglycerides ketogenic diet is performed. Young, age-matched and old animals fed with a standard chow are used as controls. It is shown that the medium-chain triglycerides ketogenic diet intake partially recovers age-related decrease of SDH activity and increases the myocardial area occupied by metabolically active mitochondria. These effects might counteract metabolic alterations leading to apoptosis-induced myocardial atrophy and failure during aging | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinate + ferricyanide | the assay is based on the reduction of ferricyanide to ferrocyanide by SDH activity and on the coupled capture of ferrocyanide by copper. The granular reaction product (copperferrocyanide) is highly electron opaque and is confined exclusively to the mitochondrial membranes.The use of a chelating agent in the incubating medium prevents the diffusion of the dark spots and guarantees their precise localization at the site of SDH activity | Rattus norvegicus | fumarate + ferrocyanide | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SDH | - |
Rattus norvegicus |
| succinate dehydrogenase | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.6 | - |
assay at | Rattus norvegicus |
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Release 2023.1 (January 2023)
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