Activating Compound | Comment | Organism | Structure |
---|---|---|---|
aripiprazole | chronic administration of the antipsychotic agent, increases SDH activity in the prefrontal cortex at high doses of 20 mg/kg body weight | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
clozapine | chronic administration of the antipsychotic agent, inhibit SDH activity only in the striatum | Rattus norvegicus | |
haloperidol | chronic administration of the antipsychotic agent, inhibits SDH activity in the hippocampus and striatum but not in the cerebellum, cortex, and prefrontal cortex | Rattus norvegicus | |
olanzapine | chronic administration of the antipsychotic agent, inhibits SDH activity only in the cerebellum, but not in the hippocampus, striatum, cortex, and prefrontal cortex | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
succinate + oxidized 2,6-dichlorophenolindophenol | in presence of phenazine methosulfate | Rattus norvegicus | fumarate + reduced 2,6-dichlorophenolindophenol | - |
? | |
succinate + oxidized 2,6-dichlorophenolindophenol | in presence of phenazine methosulfate | Rattus norvegicus | fumarate + reduced 2,6-dichloroindophenol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | cf. EC 1.3.5.1 | Rattus norvegicus |
More | cf. EC 1.3.99.1 | Rattus norvegicus |
SDH | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
2,6-dichlorophenolindophenol | in presence of phenazine methosulfate | Rattus norvegicus |