Protein Variants | Comment | Organism |
---|---|---|
D117V | reduced covalent FAD content | Saccharomyces cerevisiae |
H99L | reduced covalent FAD content | Saccharomyces cerevisiae |
K132E | mutation in Sdh4 subunit affects heme assembly | Saccharomyces cerevisiae |
K132G | mutation in Sdh4 subunit affects heme assembly | Saccharomyces cerevisiae |
K132Q | mutation in Sdh4 subunit, reduced heme content | Saccharomyces cerevisiae |
K132V | mutation in Sdh4 subunit affects heme assembly | Saccharomyces cerevisiae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-n-heptyl-4-hydroxyquinoline-N-oxide | - |
Saccharomyces cerevisiae | |
2-Thenoyltrifluoroacetone | - |
Saccharomyces cerevisiae | |
3-methylcarboxin | - |
Saccharomyces cerevisiae | |
sec-butyl-4,6-dinitrophenol | non-competitive inhibition | Saccharomyces cerevisiae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | SDH is attached to the membrane through Sdh3 and Sdh4 subunits | Saccharomyces cerevisiae | 16020 | - |
mitochondrion | - |
Saccharomyces cerevisiae | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Iron | Sdh2 subunit contains [2Fe-2S], 4[Fe-4S] and [3Fe-4S] clusters | Saccharomyces cerevisiae |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
16638 | - |
1 * 70185, + 1 * 30229, + 1 * 16675, + 1 * 16638, subunits Sdh1, Sdh2, Sdh3 and Sdh4 | Saccharomyces cerevisiae |
16675 | - |
1 * 70185, + 1 * 30229, + 1 * 16675, + 1 * 16638, subunits Sdh1, Sdh2, Sdh3 and Sdh4 | Saccharomyces cerevisiae |
30229 | - |
1 * 70185, + 1 * 30229, + 1 * 16675, + 1 * 16638, subunits Sdh1, Sdh2, Sdh3 and Sdh4 | Saccharomyces cerevisiae |
70185 | - |
1 * 70185, + 1 * 30229, + 1 * 16675, + 1 * 16638, subunits Sdh1, Sdh2, Sdh3 and Sdh4 | Saccharomyces cerevisiae |
150000 | - |
blue native gel electrophoresis | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
succinate + ubiquinone | Saccharomyces cerevisiae | - |
fumarate + ubiquinol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
succinate + ubiquinone | - |
Saccharomyces cerevisiae | fumarate + ubiquinol | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | 1 * 70185, + 1 * 30229, + 1 * 16675, + 1 * 16638, subunits Sdh1, Sdh2, Sdh3 and Sdh4 | Saccharomyces cerevisiae |
Synonyms | Comment | Organism |
---|---|---|
SDH | - |
Saccharomyces cerevisiae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | localized in Sdh1, i.e. the flavoprotein subunit | Saccharomyces cerevisiae |