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Literature summary for 1.3.5.1 extracted from

  • Maklashina, E.; Cecchini, G.
    Comparison of catalytic activity and inhibitors of quinone reactions of succinate dehydrogenase (Succinate-ubiquinone oxidoreductase) and fumarate reductase (Menaquinol-fumarate oxidoreductase) from Escherichia coli (1999), Arch. Biochem. Biophys., 369, 223-232.
    View publication on PubMed
Search for more literature for 1.3.5.1

Inhibitors

Inhibitors Comment Organism Structure
2-(n-heptyl)-4-hydroxy-quinoline N-oxide potent inhibitor of fumarate reductase, not inhibitory for succinate dehydrogenase Escherichia coli
2-alkyl-4,6-dinitrophenol-17
-
 Escherichia coli
2-alkyl-4,6-dinitrophenol-20
-
 Escherichia coli
2-alkyl-4,6-dinitrophenols derivatives of 2-alkyl-4,6-dinitrophenols, competitive inhibitors of both succinate dehydrogenase and fumarate reductase Escherichia coli
carboxin inhibits the succinate dehydrogenase in the forward and reverse reaction Escherichia coli
malonate inhibits both succinate dehydrogenase and fumarate reductase Escherichia coli
menaquinone-1 competitive inhibitor of the succinate oxidation reaction of succinate dehydrogenase Escherichia coli
Pentachlorophenol competitive inhibitor of both succinate dehydrogenase and fumarate reductase Escherichia coli
ubiquinol-2 competitive inhibitor of the fumarate reduction reaction of fumarate reductase Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information succinate-quinone and quinol-fumarate reductase reaction of succinate dehydrogenase and fumarate reductase Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Escherichia coli 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fumarate + menaquinol Escherichia coli fumarate reductase acts as part of an anaerobic respiratory chain succinate + menaquinone
-
 r
additional information Escherichia coli succinate dehydrogenase is a component of the respiratory chain and operates as a compulsory member of the Krebs cycle in mammals ?
-
 ?
succinate + ubiquinone Escherichia coli
-
 fumarate + ubiquinol
-
 r

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 succinate dehydrogenase
-
Escherichia coli
-
 fumarate reductase
-

Purification (Commentary)

Purification (Comment) Organism
of both succinate dehydrogenase and fumarate reductase using solubilization with Thesit and DEAE fast-flow chromatography Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fumarate + menaquinol fumarate reductase acts as part of an anaerobic respiratory chain Escherichia coli succinate + menaquinone
-
 r
fumarate + quinol
-
 Escherichia coli succinate + ubiquinone
-
 r
additional information succinate dehydrogenase is a component of the respiratory chain and operates as a compulsory member of the Krebs cycle in mammals Escherichia coli ?
-
 ?
succinate + ubiquinone
-
 Escherichia coli fumarate + ubiquinol
-
 r

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
 additional information succinate-quinone and quinol-fumarate reductase reaction of succinate dehydrogenase and fumarate reductase Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4 7.8 for both succinate dehydrogenase and fumarate reductase Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000075
-
 2-(n-heptyl)-4-hydroxy-quinoline N-oxide fumarate reductase, succinate oxidation reaction Escherichia coli
0.0002
-
 2-(n-heptyl)-4-hydroxy-quinoline N-oxide fumarate reductase, fumarate reduction reaction Escherichia coli
0.0013
-
 2-alkyl-4,6-dinitrophenol-17 fumarate reductase, succinate oxidation reaction Escherichia coli
0.0015
-
 2-alkyl-4,6-dinitrophenol-20 fumarate reductase, succinate oxidation reaction Escherichia coli
0.002
-
 2-alkyl-4,6-dinitrophenol-17 fumarate reductase, fumarate reduction reaction Escherichia coli
0.002
-
 2-alkyl-4,6-dinitrophenol-20 fumarate reductase, fumarate reduction reaction Escherichia coli
0.012
-
 menaquinone-1 succinate dehydrogenase, succinate oxidation reaction Escherichia coli
0.013
-
 Pentachlorophenol succinate dehydrogenase, succinate oxidation reaction Escherichia coli
0.015
-
 ubiquinol-2 fumarate reductase, fumarate reduction reaction Escherichia coli
0.017
-
 2-alkyl-4,6-dinitrophenol-17 succinate dehydrogenase, succinate oxidation reaction Escherichia coli
0.017
-
 Pentachlorophenol succinate dehydrogenase, fumarate reduction reaction Escherichia coli
0.019
-
 2-alkyl-4,6-dinitrophenol-20 succinate dehydrogenase, succinate oxidation reaction Escherichia coli
0.023
-
 Pentachlorophenol fumarate reductase, succinate oxidation reaction Escherichia coli
0.03
-
 carboxin succinate dehydrogenase, succinate oxidation reaction Escherichia coli
0.035
-
 carboxin succinate dehydrogenase, fumarate reduction reaction Escherichia coli
0.037
-
 Pentachlorophenol fumarate reductase, fumarate reduction reaction Escherichia coli