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Literature summary for 1.3.3.5 extracted from

  • Mano, N.
    Features and applications of bilirubin oxidases (2012), Appl. Microbiol. Biotechnol., 96, 301-307.
    View publication on PubMed

Application

Application Comment Organism
additional information BODs have a high efficiency of decolorizing compounds such as Trypan blue and Remazol brilliant blue R under mild pH conditions Pyricularia oryzae
additional information BODs have a high efficiency of decolorizing compounds such as Trypan blue and Remazol brilliant blue R under mild pH conditions Aspergillus sojae
additional information BODs have a high efficiency of decolorizing compounds such as Trypan blue and Remazol brilliant blue R under mild pH conditions Penicillium janthinellum
additional information BODs have a high efficiency of decolorizing compounds such as Trypan blue and Remazol brilliant blue R under mild pH conditions Ganoderma tsunodae
additional information BODs have a high efficiency of decolorizing compounds such as Trypan blue and Remazol brilliant blue R under mild pH conditions Albifimbria verrucaria
additional information BODs have a high efficiency of decolorizing compounds such as Trypan blue and Remazol brilliant blue R under mild pH conditions Pleurotus ostreatus
additional information BODs have a high efficiency of decolorizing compounds such as Trypan blue and Remazol brilliant blue R under mild pH conditions Bacillus subtilis
additional information BODs have a high efficiency of decolorizing compounds such as Trypan blue and Remazol brilliant blue R under mild pH conditions Bacillus licheniformis
additional information BODs have a high efficiency of decolorizing compounds such as Trypan blue and Remazol brilliant blue R under mild pH conditions Bacillus pumilus

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression in Pichia pastoris Albifimbria verrucaria

General Stability

General Stability Organism
after an incubation of 8 days at physiological conditions, the enzyme loses 15% of its activity Pyricularia oryzae

Inhibitors

Inhibitors Comment Organism Structure
DTT
-
Ganoderma tsunodae
EDTA
-
Ganoderma tsunodae
additional information BODs display a high tolerance towards chloride anions and other chelators Albifimbria verrucaria
additional information BODs display a high tolerance towards chloride anions and other chelators Aspergillus sojae
additional information BODs display a high tolerance towards chloride anions and other chelators Bacillus licheniformis
additional information BODs display a high tolerance towards chloride anions and other chelators, the enzyme from Bacillus pumilus is urate-, DTT-, and EDTA-insensitive Bacillus pumilus
additional information BODs display a high tolerance towards chloride anions and other chelators Bacillus subtilis
additional information BODs display a high tolerance towards chloride anions and other chelators Ganoderma tsunodae
additional information BODs display a high tolerance towards chloride anions and other chelators Penicillium janthinellum
additional information BODs display a high tolerance towards chloride anions and other chelators Pleurotus ostreatus
additional information BODs display a high tolerance towards chloride anions and other chelators, the enzyme from Magnaporthe oryzae is urate-, DTT-, and EDTA-insensitive Pyricularia oryzae
Urate
-
Ganoderma tsunodae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.008
-
bilirubin unconjugated bilirubin, pH 7.0, temperature not specified in the publication Bacillus subtilis
0.015
-
bilirubin conjugated bilirubin, pH 7.0, temperature not specified in the publication Bacillus subtilis
0.018
-
bilirubin conjugated bilirubin, pH 3.6, temperature not specified in the publication Pyricularia oryzae
0.022
-
bilirubin unconjugated bilirubin, pH 7.2, temperature not specified in the publication Bacillus pumilus
0.035
-
bilirubin conjugated bilirubin, pH 4.8, temperature not specified in the publication Bacillus pumilus
0.12
-
bilirubin conjugated bilirubin, pH 5.5, temperature not specified in the publication Albifimbria verrucaria
0.37
-
bilirubin unconjugated bilirubin, pH 8.0, temperature not specified in the publication Albifimbria verrucaria

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ bilirubin oxidase utilizes four Cu+/2+ ions to reduce O2 to water. It contains four histidine-rich copper-binding domains Pyricularia oryzae
Cu2+ bilirubin oxidase utilizes four Cu+/2+ ions to reduce O2 to water. It contains four histidine-rich copper-binding domains Aspergillus sojae
Cu2+ bilirubin oxidase utilizes four Cu+/2+ ions to reduce O2 to water. It contains four histidine-rich copper-binding domains Penicillium janthinellum
Cu2+ bilirubin oxidase utilizes four Cu+/2+ ions to reduce O2 to water. It contains four histidine-rich copper-binding domains Ganoderma tsunodae
Cu2+ bilirubin oxidase utilizes four Cu+/2+ ions to reduce O2 to water. It contains four histidine-rich copper-binding domains Albifimbria verrucaria
Cu2+ bilirubin oxidase utilizes four Cu+/2+ ions to reduce O2 to water. It contains four histidine-rich copper-binding domains Pleurotus ostreatus
Cu2+ bilirubin oxidase utilizes four Cu+/2+ ions to reduce O2 to water. It contains four histidine-rich copper-binding domains Bacillus subtilis
Cu2+ bilirubin oxidase utilizes four Cu+/2+ ions to reduce O2 to water. It contains four histidine-rich copper-binding domains Bacillus licheniformis
Cu2+ bilirubin oxidase utilizes four Cu+/2+ ions to reduce O2 to water. It contains four histidine-rich copper-binding domains Bacillus pumilus
additional information BODs display a high tolerance towards chloride anions and other chelators Pyricularia oryzae
additional information BODs display a high tolerance towards chloride anions and other chelators Aspergillus sojae
additional information BODs display a high tolerance towards chloride anions and other chelators Penicillium janthinellum
additional information BODs display a high tolerance towards chloride anions and other chelators Ganoderma tsunodae
additional information BODs display a high tolerance towards chloride anions and other chelators Albifimbria verrucaria
additional information BODs display a high tolerance towards chloride anions and other chelators Pleurotus ostreatus
additional information BODs display a high tolerance towards chloride anions and other chelators Bacillus subtilis
additional information BODs display a high tolerance towards chloride anions and other chelators Bacillus licheniformis
additional information BODs display a high tolerance towards chloride anions and other chelators Bacillus pumilus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 bilirubin + O2 Pyricularia oryzae
-
2 biliverdin + 2 H2O
-
?
2 bilirubin + O2 Aspergillus sojae
-
2 biliverdin + 2 H2O
-
?
2 bilirubin + O2 Penicillium janthinellum
-
2 biliverdin + 2 H2O
-
?
2 bilirubin + O2 Ganoderma tsunodae
-
2 biliverdin + 2 H2O
-
?
2 bilirubin + O2 Albifimbria verrucaria
-
2 biliverdin + 2 H2O
-
?
2 bilirubin + O2 Pleurotus ostreatus
-
2 biliverdin + 2 H2O
-
?
2 bilirubin + O2 Bacillus subtilis
-
2 biliverdin + 2 H2O
-
?
2 bilirubin + O2 Bacillus licheniformis
-
2 biliverdin + 2 H2O
-
?
2 bilirubin + O2 Bacillus pumilus
-
2 biliverdin + 2 H2O
-
?
additional information Pyricularia oryzae in addition to traditional laccase substrates like 2, 2'-azino-bis (3-ethylbenzthiazoline-6-sulfonate), syringaldazine, or 2,6-dimethoxyphenol, the enzyme catalyzes also the oxidation of conjugated and/or unconjugated bilirubin ?
-
?
additional information Aspergillus sojae in addition to traditional laccase substrates like 2, 2'-azino-bis (3-ethylbenzthiazoline-6-sulfonate), syringaldazine, or 2,6-dimethoxyphenol, the enzyme catalyzes also the oxidation of conjugated and/or unconjugated bilirubin ?
-
?
additional information Penicillium janthinellum in addition to traditional laccase substrates like 2, 2'-azino-bis (3-ethylbenzthiazoline-6-sulfonate), syringaldazine, or 2,6-dimethoxyphenol, the enzyme catalyzes also the oxidation of conjugated and/or unconjugated bilirubin ?
-
?
additional information Ganoderma tsunodae in addition to traditional laccase substrates like 2, 2'-azino-bis (3-ethylbenzthiazoline-6-sulfonate), syringaldazine, or 2,6-dimethoxyphenol, the enzyme catalyzes also the oxidation of conjugated and/or unconjugated bilirubin ?
-
?
additional information Albifimbria verrucaria in addition to traditional laccase substrates like 2, 2'-azino-bis (3-ethylbenzthiazoline-6-sulfonate), syringaldazine, or 2,6-dimethoxyphenol, the enzyme catalyzes also the oxidation of conjugated and/or unconjugated bilirubin ?
-
?
additional information Pleurotus ostreatus in addition to traditional laccase substrates like 2, 2'-azino-bis (3-ethylbenzthiazoline-6-sulfonate), syringaldazine, or 2,6-dimethoxyphenol, the enzyme catalyzes also the oxidation of conjugated and/or unconjugated bilirubin ?
-
?
additional information Bacillus subtilis in addition to traditional laccase substrates like 2, 2'-azino-bis (3-ethylbenzthiazoline-6-sulfonate), syringaldazine, or 2,6-dimethoxyphenol, the enzyme catalyzes also the oxidation of conjugated and/or unconjugated bilirubin ?
-
?
additional information Bacillus licheniformis in addition to traditional laccase substrates like 2, 2'-azino-bis (3-ethylbenzthiazoline-6-sulfonate), syringaldazine, or 2,6-dimethoxyphenol, the enzyme catalyzes also the oxidation of conjugated and/or unconjugated bilirubin ?
-
?
additional information Bacillus pumilus in addition to traditional laccase substrates like 2, 2'-azino-bis (3-ethylbenzthiazoline-6-sulfonate), syringaldazine, or 2,6-dimethoxyphenol, the enzyme catalyzes also the oxidation of conjugated and/or unconjugated bilirubin ?
-
?

Organism

Organism UniProt Comment Textmining
Albifimbria verrucaria Q12737
-
-
Aspergillus sojae
-
-
-
Bacillus licheniformis Q65MU7
-
-
Bacillus pumilus A8FAG9
-
-
Bacillus subtilis P07788
-
-
Ganoderma tsunodae
-
-
-
Penicillium janthinellum
-
-
-
Pleurotus ostreatus Q9UVY4
-
-
Pyricularia oryzae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 bilirubin + O2
-
Pyricularia oryzae 2 biliverdin + 2 H2O
-
?
2 bilirubin + O2
-
Aspergillus sojae 2 biliverdin + 2 H2O
-
?
2 bilirubin + O2
-
Penicillium janthinellum 2 biliverdin + 2 H2O
-
?
2 bilirubin + O2
-
Ganoderma tsunodae 2 biliverdin + 2 H2O
-
?
2 bilirubin + O2
-
Albifimbria verrucaria 2 biliverdin + 2 H2O
-
?
2 bilirubin + O2
-
Pleurotus ostreatus 2 biliverdin + 2 H2O
-
?
2 bilirubin + O2
-
Bacillus subtilis 2 biliverdin + 2 H2O
-
?
2 bilirubin + O2
-
Bacillus licheniformis 2 biliverdin + 2 H2O
-
?
2 bilirubin + O2
-
Bacillus pumilus 2 biliverdin + 2 H2O
-
?
additional information in addition to traditional laccase substrates like 2, 2'-azino-bis (3-ethylbenzthiazoline-6-sulfonate), syringaldazine, or 2,6-dimethoxyphenol, the enzyme catalyzes also the oxidation of conjugated and/or unconjugated bilirubin Pyricularia oryzae ?
-
?
additional information in addition to traditional laccase substrates like 2, 2'-azino-bis (3-ethylbenzthiazoline-6-sulfonate), syringaldazine, or 2,6-dimethoxyphenol, the enzyme catalyzes also the oxidation of conjugated and/or unconjugated bilirubin Aspergillus sojae ?
-
?
additional information in addition to traditional laccase substrates like 2, 2'-azino-bis (3-ethylbenzthiazoline-6-sulfonate), syringaldazine, or 2,6-dimethoxyphenol, the enzyme catalyzes also the oxidation of conjugated and/or unconjugated bilirubin Penicillium janthinellum ?
-
?
additional information in addition to traditional laccase substrates like 2, 2'-azino-bis (3-ethylbenzthiazoline-6-sulfonate), syringaldazine, or 2,6-dimethoxyphenol, the enzyme catalyzes also the oxidation of conjugated and/or unconjugated bilirubin Ganoderma tsunodae ?
-
?
additional information in addition to traditional laccase substrates like 2, 2'-azino-bis (3-ethylbenzthiazoline-6-sulfonate), syringaldazine, or 2,6-dimethoxyphenol, the enzyme catalyzes also the oxidation of conjugated and/or unconjugated bilirubin Albifimbria verrucaria ?
-
?
additional information in addition to traditional laccase substrates like 2, 2'-azino-bis (3-ethylbenzthiazoline-6-sulfonate), syringaldazine, or 2,6-dimethoxyphenol, the enzyme catalyzes also the oxidation of conjugated and/or unconjugated bilirubin Pleurotus ostreatus ?
-
?
additional information in addition to traditional laccase substrates like 2, 2'-azino-bis (3-ethylbenzthiazoline-6-sulfonate), syringaldazine, or 2,6-dimethoxyphenol, the enzyme catalyzes also the oxidation of conjugated and/or unconjugated bilirubin Bacillus subtilis ?
-
?
additional information in addition to traditional laccase substrates like 2, 2'-azino-bis (3-ethylbenzthiazoline-6-sulfonate), syringaldazine, or 2,6-dimethoxyphenol, the enzyme catalyzes also the oxidation of conjugated and/or unconjugated bilirubin Bacillus licheniformis ?
-
?
additional information in addition to traditional laccase substrates like 2, 2'-azino-bis (3-ethylbenzthiazoline-6-sulfonate), syringaldazine, or 2,6-dimethoxyphenol, the enzyme catalyzes also the oxidation of conjugated and/or unconjugated bilirubin Bacillus pumilus ?
-
?

Synonyms

Synonyms Comment Organism
BOD
-
Pyricularia oryzae
BOD
-
Aspergillus sojae
BOD
-
Penicillium janthinellum
BOD
-
Albifimbria verrucaria
BOD
-
Bacillus licheniformis
BOD
-
Bacillus pumilus
CotA
-
Ganoderma tsunodae
CotA
-
Pleurotus ostreatus
CotA
-
Bacillus subtilis
CotA
-
Bacillus licheniformis
CotA
-
Bacillus pumilus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
40
-
-
Albifimbria verrucaria
60
-
-
Pyricularia oryzae
80
-
-
Ganoderma tsunodae
80
-
-
Pleurotus ostreatus
80
-
-
Bacillus subtilis
80
-
-
Bacillus licheniformis
80
-
-
Bacillus pumilus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
37
-
half-life over 300 min Pyricularia oryzae
37
-
loss of 50% activity after 90 min Ganoderma tsunodae
60
-
half-life of the wild-type enzyme is 15 min, and of the recombinant enzyme 90 min Albifimbria verrucaria
60
-
half-life over 70 min Pyricularia oryzae
80
-
half-life above 100 min at 80°C Ganoderma tsunodae
80
-
half-life above 100 min at 80°C Pleurotus ostreatus
80
-
half-life above 100 min at 80°C Bacillus subtilis
80
-
half-life above 100 min at 80°C Bacillus licheniformis
80
-
half-life above 100 min at 80°C Bacillus pumilus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
29
-
bilirubin conjugated bilirubin, pH 3.6, temperature not specified in the publication Pyricularia oryzae
67
-
bilirubin conjugated bilirubin, pH 4.8, temperature not specified in the publication Bacillus pumilus
70
-
bilirubin unconjugated bilirubin, pH 7.2, temperature not specified in the publication Bacillus pumilus
94.3
-
bilirubin unconjugated bilirubin, pH 8.0, temperature not specified in the publication Albifimbria verrucaria
117
-
bilirubin conjugated bilirubin, pH 5.5, temperature not specified in the publication Albifimbria verrucaria

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
BODs display a high activity and stability at neutral pH Pyricularia oryzae
additional information
-
BODs display a high activity and stability at neutral pH Aspergillus sojae
additional information
-
BODs display a high activity and stability at neutral pH Penicillium janthinellum
additional information
-
BODs display a high activity and stability at neutral pH Ganoderma tsunodae
additional information
-
BODs display a high activity and stability at neutral pH Albifimbria verrucaria
additional information
-
BODs display a high activity and stability at neutral pH Bacillus subtilis
additional information
-
BODs display a high activity and stability at neutral pH Bacillus licheniformis
additional information
-
BODs display a high activity and stability at neutral pH Bacillus pumilus
7
-
BODs display a high activity and stability at neutral pH Pleurotus ostreatus

pH Stability

pH Stability pH Stability Maximum Comment Organism
additional information
-
BODs display a high activity and stability at neutral pH Pyricularia oryzae
additional information
-
BODs display a high activity and stability at neutral pH Aspergillus sojae
additional information
-
BODs display a high activity and stability at neutral pH Penicillium janthinellum
additional information
-
BODs display a high activity and stability at neutral pH Ganoderma tsunodae
additional information
-
BODs display a high activity and stability at neutral pH Albifimbria verrucaria
additional information
-
BODs display a high activity and stability at neutral pH Bacillus subtilis
additional information
-
BODs display a high activity and stability at neutral pH Bacillus licheniformis
additional information
-
BODs display a high activity and stability at neutral pH Bacillus pumilus
7
-
BODs display a high activity and stability at neutral pH Pleurotus ostreatus

General Information

General Information Comment Organism
evolution bilirubin oxidase (BOD) is a sub-group of multicopper oxidases (MCOs) also utilizing four Cu+/2+ ions Pyricularia oryzae
evolution bilirubin oxidase (BOD) is a sub-group of multicopper oxidases (MCOs) also utilizing four Cu+/2+ ions Aspergillus sojae
evolution bilirubin oxidase (BOD) is a sub-group of multicopper oxidases (MCOs) also utilizing four Cu+/2+ ions Penicillium janthinellum
evolution bilirubin oxidase (BOD) is a sub-group of multicopper oxidases (MCOs) also utilizing four Cu+/2+ ions Ganoderma tsunodae
evolution bilirubin oxidase (BOD) is a sub-group of multicopper oxidases (MCOs) also utilizing four Cu+/2+ ions Albifimbria verrucaria
evolution bilirubin oxidase (BOD) is a sub-group of multicopper oxidases (MCOs) also utilizing four Cu+/2+ ions Pleurotus ostreatus
evolution bilirubin oxidase (BOD) is a sub-group of multicopper oxidases (MCOs) also utilizing four Cu+/2+ ions Bacillus subtilis
evolution bilirubin oxidase (BOD) is a sub-group of multicopper oxidases (MCOs) also utilizing four Cu+/2+ ions Bacillus licheniformis
evolution bilirubin oxidase (BOD) is a sub-group of multicopper oxidases (MCOs) also utilizing four Cu+/2+ ions Bacillus pumilus
additional information BODs have a high efficiency of decolorizing compounds such as Trypan blue and Remazol brilliant blue R under mild pH conditions Pyricularia oryzae
additional information BODs have a high efficiency of decolorizing compounds such as Trypan blue and Remazol brilliant blue R under mild pH conditions Aspergillus sojae
additional information BODs have a high efficiency of decolorizing compounds such as Trypan blue and Remazol brilliant blue R under mild pH conditions Penicillium janthinellum
additional information BODs have a high efficiency of decolorizing compounds such as Trypan blue and Remazol brilliant blue R under mild pH conditions Ganoderma tsunodae
additional information BODs have a high efficiency of decolorizing compounds such as Trypan blue and Remazol brilliant blue R under mild pH conditions Albifimbria verrucaria
additional information BODs have a high efficiency of decolorizing compounds such as Trypan blue and Remazol brilliant blue R under mild pH conditions Pleurotus ostreatus
additional information BODs have a high efficiency of decolorizing compounds such as Trypan blue and Remazol brilliant blue R under mild pH conditions Bacillus subtilis
additional information BODs have a high efficiency of decolorizing compounds such as Trypan blue and Remazol brilliant blue R under mild pH conditions Bacillus licheniformis
additional information BODs have a high efficiency of decolorizing compounds such as Trypan blue and Remazol brilliant blue R under mild pH conditions Bacillus pumilus

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1000
-
bilirubin conjugated bilirubin, pH 4.8, temperature not specified in the publication Bacillus pumilus
1610
-
bilirubin conjugated bilirubin, pH 3.6, temperature not specified in the publication Pyricularia oryzae
2500
-
bilirubin unconjugated bilirubin, pH 8.0, temperature not specified in the publication Albifimbria verrucaria
3000
-
bilirubin unconjugated bilirubin, pH 7.2, temperature not specified in the publication Bacillus pumilus
9800
-
bilirubin conjugated bilirubin, pH 5.5, temperature not specified in the publication Albifimbria verrucaria