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Literature summary for 1.3.3.4 extracted from

  • Wang, B.; Wen, X.; Xi, Z.
    Molecular simulations bring new insights into protoporphyrinogen IX oxidase/protoporphyrinogen IX interaction modes (2016), Mol. Inform., 35, 476-482 .
    View publication on PubMed
Search for more literature for 1.3.3.4

Application

Application Comment Organism
drug development enzyme PPO is an excellent target for commercial herbicides Nicotiana tabacum

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Nicotiana tabacum 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protoporphyrinogen IX + 3 O2 Nicotiana tabacum
-
 protoporphyrin IX + 3 H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Nicotiana tabacum O24164
-
-

Reaction

Reaction Comment Organism Reaction ID
protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2 reaction scheme involving FAD, overview Nicotiana tabacum
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protoporphyrinogen IX + 3 O2
-
 Nicotiana tabacum protoporphyrin IX + 3 H2O2
-
 ?

Synonyms

Synonyms Comment Organism
mtPPO
-
 Nicotiana tabacum
PPO
-
 Nicotiana tabacum
protoporphyrinogen IX oxidase
-
 Nicotiana tabacum

Cofactor

Cofactor Comment Organism Structure
FAD modeling of binding structure, overview Nicotiana tabacum

General Information

General Information Comment Organism
malfunction deficient activity of PPO causes the accumulation and nonenzymatic oxidation of protogen IX leading to cellular damage. For green plants, inhibition of PPO leads to the rapid bleaching and desiccation of photosynthetically active parts of the plant Nicotiana tabacum
additional information analysis of binding mode of protogen IX in the Nicotiana tabacum protoporphyrinogen IX oxidase (mtPPO) by performing a computational docking followed by molecular simulations, quantum mechanics calculations, and an integrated analysis, overview. Several potential key residues, e.g. Thr70, Arg233, Ser235, Ser474 and Lys477, are identified. Residue Arg98 is necessary for binding of protogen IX. Comparison of the Nicotiana tabacum enzyme with the human enzyme. Modeling of ligand binding structures Nicotiana tabacum
physiological function protoporphyrinogen IX oxidase catalyzes the oxidation of protoporphyrinogen IX (protogen IX) to protoporphyrin IX (proto IX) in the haem/chlorophyll biosynthetic pathway Nicotiana tabacum