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Literature summary for 1.3.3.3 extracted from

  • Li, T.; Woods, J.S.
    Cloning, expression, and biochemical properties of CPOX4, a genetic variant of coproporphyrinogen oxidase that affects susceptibility to mercury toxicity in humans (2009), Toxicol. Sci., 109, 228-236.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.3.3

Application

Application Comment Organism
medicine natural polymorphism A814C leading to mutation N272H results in twofold decrease in affinity for coproporphyrinogen-III. Specific activity in liver samples is 40-50% lower than in wild-type, mutation may predispose to impaired heme biosynthesis Homo sapiens

Protein Variants

Protein Variants Comment Organism
N272H natural polymorphism, twofold decrease in affinity for coproporphyrinogen-III. Specific activity in liver samples is 40-50% lower than in wild-type Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Hg2+ acts comparably on wild-type and mutant N272H Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00029
-
 Coproporphyrinogen-III wild-type, pH 7.2, 37°C Homo sapiens
0.00054
-
 Coproporphyrinogen-III mutant N272H, pH 7.2, 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
coproporphyrinogen-III + O2 + 2 H+
-
 Homo sapiens protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.6
-
 Coproporphyrinogen-III mutant N272H, pH 7.2, 37°C Homo sapiens
1.8
-
 Coproporphyrinogen-III wild-type, pH 7.2, 37°C Homo sapiens