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Literature summary for 1.3.3.3 extracted from

  • Cooper, C.L.; Lash, T.D.; Jones, M.A.
    Kinetic evaluation of human cloned coproporphyrinogen oxidase using a ring isomer of the natural substrate (2005), Med. Sci. Monit., 11, BR420-BR425.
    View publication on PubMed

Application

Application Comment Organism
medicine increase of severity of porphyrias with monovinyl accumulation, ability of the increased levels of C-IV to compete with the authentic substrate has important implications for clinical porphyrias Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli BL21(DE3)RIL Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00013
-
Coproporphyrinogen-III with monovinyl product Homo sapiens
0.00065
-
coproporphyrinogen-IV with monovinyl product Homo sapiens
0.00068
-
Coproporphyrinogen-III total product Homo sapiens
0.0007
-
Coproporphyrinogen-III with divinyl product Homo sapiens
0.00078
-
coproporphyrinogen-IV total product Homo sapiens
0.00083
-
coproporphyrinogen-IV with divinyl product Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37700
-
37700, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni2+ affinity chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
coproporphyrinogen-III + O2 + 2 H+ small amount of the monovinyl intermediate Homo sapiens protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
?
coproporphyrinogen-IV + O2 monovinyl intermediate that accumulates before being converted to an isomer Homo sapiens protoporphyrinogen-XIII + 2 CO2 + 2 H2O
-
?

Subunits

Subunits Comment Organism
? 37700, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
copro'gen oxidase
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0033
-
Coproporphyrinogen-III with monovinyl product Homo sapiens
0.01167
-
coproporphyrinogen-IV with divinyl product Homo sapiens
0.0283
-
coproporphyrinogen-IV with monovinyl product Homo sapiens
0.043
-
coproporphyrinogen-IV total product Homo sapiens
0.055
-
Coproporphyrinogen-III with divinyl product Homo sapiens
0.06
-
Coproporphyrinogen-III total product Homo sapiens