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Literature summary for 1.3.3.3 extracted from

  • Hanaoka, R.; Katayama, S.; Dawid, I.B.; Kawahara, A.
    Characterization of the heme synthesis enzyme coproporphyrinogen oxidase (CPO) in zebrafish erythrogenesis (2006), Genes Cells, 11, 293-303.
    View publication on PubMed

Application

Application Comment Organism
medicine function of CPO in heme biosynthesis is apparently conserved between zebrafish and human, suggesting that CPO-MO-injected zebrafish embryos might be a useful in vivo assay system to measure the biological activity of human CPO mutations Danio rerio

Protein Variants

Protein Variants Comment Organism
additional information knockdown of zebrafish CPO using anti-sense morpholinos leads to a significant suppression of hemoglobin production without apparent reduction of blood cells, injection of human CPO RNA, but not a mutant CPO RNA similar to a mutant responsible for a hereditary coproporphyria, restores hemoglobin production in the CPO-MO-injected embryos, expression of CPO in the ICM is severely suppressed in both vlad tepes/gata1 mutants and in biklf-MO-injected embryos Danio rerio

Organism

Organism UniProt Comment Textmining
Danio rerio
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zebrafish strain AB or Riken-Wako
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Source Tissue

Source Tissue Comment Organism Textmining
embryo
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Danio rerio
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additional information intermediate cell mass Danio rerio
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Synonyms

Synonyms Comment Organism
CPO
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Danio rerio