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Literature summary for 1.3.3.12 extracted from
- Occurrence in yeast of L-galactonolactone oxidase which is similar to a key enzyme for ascorbic acid biosynthesis in animals, L-gulonolactone oxidase (1978), Arch. Biochem. Biophys., 191, 479-486.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| PCMB | - |
Saccharomyces cerevisiae |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Saccharomyces cerevisiae | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 56000 | - |
4 * 56000, SDS-PAGE | Saccharomyces cerevisiae |
| 290000 | - |
gel filtration | Saccharomyces cerevisiae |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-galactono-1,4-lactone + O2 | Saccharomyces cerevisiae | enzyme catalyzes the last step of L-ascorbic acid biosynthesis | L-ascorbate + H2O2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Saccharomyces cerevisiae |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.76 | - |
- |
Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-altronolactone + O2 | 68% of the activity with L-galactono-1,4-lactone | Saccharomyces cerevisiae | ? | - |
? | |
| L-galactono-1,4-lactone + O2 | - |
Saccharomyces cerevisiae | L-ascorbate + H2O2 | - |
? | |
| L-galactono-1,4-lactone + O2 | enzyme catalyzes the last step of L-ascorbic acid biosynthesis | Saccharomyces cerevisiae | L-ascorbate + H2O2 | - |
? | |
| L-gulonolactone + O2 | 32% of the activity with L-galactono-1,4-lactone | Saccharomyces cerevisiae | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | 4 * 56000, SDS-PAGE | Saccharomyces cerevisiae |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | enzyme contains a covalently bound flavin | Saccharomyces cerevisiae | |
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Release 2023.1 (January 2023)
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