Literature summary for 1.3.3.11 extracted from

Toyama, H.; Fukumoto, H.; Saeki, M.; Matsushita, K.; Adachi, O.; Lidstrom, M.E.
PqqC/D, which converts a biosynthetic intermediate to pyrroloquinoline quinone (2002), Biochem. Biophys. Res. Commun., 299, 268-272.

Search for more literature for 1.3.3.11

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	no dependence on NADH or NADPH in purified enzyme preparation	Methylorubrum extorquens

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli DHalpha	Methylorubrum extorquens

Protein Variants

Protein Variants	Comment	Organism
additional information	N60I mutation detected in PqqC deficiency mutant	Methylorubrum extorquens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
42000	-	3 * 42000, SDS-PAGE	Methylorubrum extorquens
113000	-	gel filtration	Methylorubrum extorquens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic acid + O2	Methylorubrum extorquens	synthesis of the pyrroloquinoline quinone (PQQ), that serves as prosthetic group for many bacterial enzymes	4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + H2O2 + H2O	the product is pyrroloquinoline quinone (PQQ)	?
3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic acid + O2	Methylorubrum extorquens ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1	synthesis of the pyrroloquinoline quinone (PQQ), that serves as prosthetic group for many bacterial enzymes	4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + H2O2 + H2O	the product is pyrroloquinoline quinone (PQQ)	?

Organism

Organism	UniProt	Comment	Textmining
Methylorubrum extorquens	-	fusion protein of PqqC with PqqD	-
Methylorubrum extorquens ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1	-	fusion protein of PqqC with PqqD	-

Purification (Commentary)

Purification (Comment)	Organism
partial purification of recombinant protein	Methylorubrum extorquens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic acid + O2	-	Methylorubrum extorquens	4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + H2O2 + H2O	the product is pyrroloquinoline quinone (PQQ)	?
3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic acid + O2	synthesis of the pyrroloquinoline quinone (PQQ), that serves as prosthetic group for many bacterial enzymes	Methylorubrum extorquens	4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + H2O2 + H2O	the product is pyrroloquinoline quinone (PQQ)	?
3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic acid + O2	-	Methylorubrum extorquens ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1	4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + H2O2 + H2O	the product is pyrroloquinoline quinone (PQQ)	?
3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic acid + O2	synthesis of the pyrroloquinoline quinone (PQQ), that serves as prosthetic group for many bacterial enzymes	Methylorubrum extorquens ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1	4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + H2O2 + H2O	the product is pyrroloquinoline quinone (PQQ)	?

Subunits

Subunits	Comment	Organism
trimer	3 * 42000, SDS-PAGE	Methylorubrum extorquens

Synonyms

Synonyms	Comment	Organism
PqqC	-	Methylorubrum extorquens

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Release 2023.1 (January 2023)