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Literature summary for 1.3.1.92 extracted from
- The activity of the artemisinic aldehyde ?11(13) reductase promoter is important for artemisinin yield in different chemotypes of Artemisia annua L. (2015), Plant Mol. Biol., 88, 325-340 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene DBR2, cloning, sequencing, and analysis of the promoter of the DBR2 gene, detailed overview. The activity of the artemisinic aldehyde DELTA11(13) reductase promoter is important for artemisinin yield in different chemotypes of Artemisia annua, quantitative real-time PCR expression analysis, overview | Artemisia annua |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| artemisinic aldehyde + NADPH + H+ | Artemisia annua | - |
(11R)-dihydroartemisinic aldehyde + NADP+ | - |
? |  |
| additional information | Artemisia annua | GC-MS analysis of dihydroartemisinic acid synthesized in different plant varieties, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Artemisia annua | C5H429 | cvs. 2/39, Chongqing, and Anamed with high artemisin production, and cvs. Meise, Iran#8, Iran#14, Iran#24, and Iran#47 with low artemisin production | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| flower bud | - |
Artemisia annua | - |
| leaf | - |
Artemisia annua | - |
| additional information | enzyme expression levels in different plant varieties, overview | Artemisia annua | - |
| secretory trichome | - |
Artemisia annua | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| artemisinic aldehyde + NADPH + H+ | - |
Artemisia annua | (11R)-dihydroartemisinic aldehyde + NADP+ | - |
? | |
| additional information | GC-MS analysis of dihydroartemisinic acid synthesized in different plant varieties, overview | Artemisia annua | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Dbr2 | - |
Artemisia annua |
| double bond reductase 2 | - |
Artemisia annua |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Artemisia annua | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme plays an important role in the biosynthesis of the antimalarial artemisinin in Artemisia annua. The high artemisin producing plant varieties 2/39, Chongqing, and Anamed produce more artemisinin than arteannuin B, while the low artemisin producing plant varieties Meise, Iran#8, Iran#14, Iran#24, and Iran#47 produce more arteannuin B than artemisinin | Artemisia annua |
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Release 2023.1 (January 2023)
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