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Literature summary for 1.3.1.92 extracted from

  • Zhou, L.; Yang, G.; Sun, H.; Tang, J.; Yang, J.; Wang, Y.; Garran, T.A.; Guo, L.
    Effects of different doses of cadmium on secondary metabolites and gene expression in Artemisia annua L (2017), Front. Med., 11, 137-146 .
    View publication on PubMed
Search for more literature for 1.3.1.92

Application

Application Comment Organism
medicine artemisinin is the main ingredient for malaria prevention. The World Health Organization recommends artemisinin combination therapies (ACT) as the first-line therapy for malaria worldwide Artemisia annua
synthesis for enhanced artemisin production, Appropriate doses of Cd can increase the concentrations of artemisinic metabolites at a certain time point by upregulating the relative expression levels of key enzyme genes involved in artemisinin biosynthesis Artemisia annua

Cloned(Commentary)

Cloned (Comment) Organism
gene DBR2, quantitative real-time PCR expression analysis Artemisia annua

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
artemisinic aldehyde + NADPH + H+ Artemisia annua
-
 (11R)-dihydroartemisinic aldehyde + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Artemisia annua C5H429 cv. guihao third
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
 Artemisia annua
-
additional information artemisinin is mainly produced and stored in the glandular secretory trichomes on leaves, stems, and inflorescences Artemisia annua
-
stem
-
 Artemisia annua
-
trichome
-
 Artemisia annua
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
artemisinic aldehyde + NADPH + H+
-
 Artemisia annua (11R)-dihydroartemisinic aldehyde + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
Dbr2
-
 Artemisia annua

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Artemisia annua

Expression

Organism Comment Expression
Artemisia annua the enzyme DBR2 is induced by 0.12 mmol/l of cadmium. Appropriate doses of cadmium can increase the concentrations of artemisinic metabolites at a certain time point by upregulating the relative expression levels of key enzyme genes involved in artemisinin biosynthesis, overview up

General Information

General Information Comment Organism
metabolism the final step of artemisin biosynthesis involves two genes, a double bond reductase (DBR2) and an aldehyde dehydrogenase (ALDH1) Artemisia annua