Literature summary for 1.3.1.9 extracted from

Owono Owono, L.C.; Ntie-Kang, F.; Keita, M.; Megnassan, E.; Frecer, V.; Miertus, S.
Virtually designed triclosan-based inhibitors of enoyl-acyl carrier protein reductase of Mycobacterium tuberculosis and of Plasmodium falciparum (2015), Mol. Inform., 34, 292-307.

Inhibitors

Inhibitors	Comment	Organism
2-(2,4-dichlorophenoxy)-5-(2-methylbutyl)phenol	-	Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-(2-methylbutyl)phenol	-	Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-(2-methylpropyl)phenol	-	Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-(2-methylpropyl)phenol	-	Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-(2-phenylethyl)phenol	-	Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-(2-phenylethyl)phenol	-	Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-(3-methylbutyl)phenol	-	Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-(3-methylbutyl)phenol	-	Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-(3-phenylpropyl)phenol	-	Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-(3-phenylpropyl)phenol	-	Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-(4-phenylbutyl)phenol	-	Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-(4-phenylbutyl)phenol	-	Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-ethylphenol	-	Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-ethylphenol	-	Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-methylphenol	-	Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-methylphenol	-	Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-propylphenol	-	Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-propylphenol	-	Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-[(2-methylphenyl)methyl]phenol	-	Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-[(2-methylphenyl)methyl]phenol	-	Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-[(3-methylphenyl)methyl]phenol	-	Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-[(3-methylphenyl)methyl]phenol	-	Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-[(4-fluorophenyl)methyl]phenol	-	Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-[(4-fluorophenyl)methyl]phenol	-	Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-[(pyridin-2-yl)methyl]phenol	-	Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-[(pyridin-2-yl)methyl]phenol	-	Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-[(pyridin-3-yl)methyl]phenol	-	Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-[(pyridin-3-yl)methyl]phenol	-	Plasmodium falciparum
2-[2-(dimethylamino)-4-sulfanylphenoxy]-5-{[(2-phenylethyl)amino]methyl}phenol	-	Mycobacterium tuberculosis
2-[2-(dimethylamino)-4-sulfanylphenoxy]-5-{[(2-phenylethyl)amino]methyl}phenol	-	Plasmodium falciparum
2-[4-({[(2,3-dihydro-1-benzofuran-6-yl)methyl]amino}methyl)-2-hydroxyphenoxy]-5-methylbenzonitrile	-	Mycobacterium tuberculosis
2-[4-({[(2,3-dihydro-1-benzofuran-6-yl)methyl]amino}methyl)-2-hydroxyphenoxy]-5-methylbenzonitrile	-	Plasmodium falciparum
3'-methyl-4-[2-(methylamino)-4-(3-methylbutyl)phenoxy][1,1'-biphenyl]-3-ol	-	Mycobacterium tuberculosis
3'-methyl-4-[2-(methylamino)-4-(3-methylbutyl)phenoxy][1,1'-biphenyl]-3-ol	-	Plasmodium falciparum
3'-methyl-4-[2-(methylamino)-4-(propan-2-yl)phenoxy][1,1'-biphenyl]-3-ol	-	Mycobacterium tuberculosis
3'-methyl-4-[2-(methylamino)-4-(propan-2-yl)phenoxy][1,1'-biphenyl]-3-ol	-	Plasmodium falciparum
3'-methyl-4-{[3-(methylamino)[1,1'-biphenyl]-4-yl]oxy}[1,1'-biphenyl]-3-ol	-	Mycobacterium tuberculosis
3'-methyl-4-{[3-(methylamino)[1,1'-biphenyl]-4-yl]oxy}[1,1'-biphenyl]-3-ol	-	Plasmodium falciparum
3-chloro-4-[2-hydroxy-4-[(2-methylphenyl)methyl]phenoxy]benzonitrile	-	Mycobacterium tuberculosis
3-chloro-4-[2-hydroxy-4-[(2-methylphenyl)methyl]phenoxy]benzonitrile	-	Plasmodium falciparum
3-chloro-4-[2-hydroxy-4-[(pyridin-4-yl)methyl]phenoxy]benzonitrile	-	Mycobacterium tuberculosis
3-chloro-4-[2-hydroxy-4-[(pyridin-4-yl)methyl]phenoxy]benzonitrile	-	Plasmodium falciparum
4-[(3-ethyl[1,1'-biphenyl]-4-yl)oxy]-3'-methyl[1,1'-biphenyl]-3-ol	-	Mycobacterium tuberculosis
4-[(3-ethyl[1,1'-biphenyl]-4-yl)oxy]-3'-methyl[1,1'-biphenyl]-3-ol	-	Plasmodium falciparum
4-[2-(dimethylamino)-4-(3-methylbutyl)phenoxy]-3'-methyl[1,1'-biphenyl]-3-ol	-	Mycobacterium tuberculosis
4-[2-(dimethylamino)-4-(3-methylbutyl)phenoxy]-3'-methyl[1,1'-biphenyl]-3-ol	-	Plasmodium falciparum
4-[2-(dimethylamino)-4-(propan-2-yl)phenoxy]-3'-methyl[1,1'-biphenyl]-3-ol	-	Mycobacterium tuberculosis
4-[2-(dimethylamino)-4-(propan-2-yl)phenoxy]-3'-methyl[1,1'-biphenyl]-3-ol	-	Plasmodium falciparum
4-[2-ethyl-4-(3-methylbutyl)phenoxy]-3'-methyl[1,1'-biphenyl]-3-ol	-	Mycobacterium tuberculosis
4-[2-ethyl-4-(3-methylbutyl)phenoxy]-3'-methyl[1,1'-biphenyl]-3-ol	-	Plasmodium falciparum
4-[2-ethyl-4-(propan-2-yl)phenoxy]-3'-methyl[1,1'-biphenyl]-3-ol	-	Mycobacterium tuberculosis
4-[2-ethyl-4-(propan-2-yl)phenoxy]-3'-methyl[1,1'-biphenyl]-3-ol	-	Plasmodium falciparum
4-[4-({[2-(4-chlorophenyl)ethyl]amino}methyl)-2-hydroxyphenoxy]-3-(methylamino)anilinium	-	Mycobacterium tuberculosis
4-[4-({[2-(4-chlorophenyl)ethyl]amino}methyl)-2-hydroxyphenoxy]-3-(methylamino)anilinium	-	Plasmodium falciparum
4-{4-[(benzylamino)methyl]-2-hydroxyphenoxy}-3-chlorobenzonitrile	-	Mycobacterium tuberculosis
4-{4-[(benzylamino)methyl]-2-hydroxyphenoxy}-3-chlorobenzonitrile	-	Plasmodium falciparum
4-{[3-(dimethylamino)[1,1'-biphenyl]-4-yl]oxy}-3'-methyl[1,1'-biphenyl]-3-ol	-	Mycobacterium tuberculosis
4-{[3-(dimethylamino)[1,1'-biphenyl]-4-yl]oxy}-3'-methyl[1,1'-biphenyl]-3-ol	-	Plasmodium falciparum
5-(anilinomethyl)-2-[(3-ethyl[1,1'-biphenyl]-4-yl)oxy]phenol	-	Mycobacterium tuberculosis
5-(anilinomethyl)-2-[(3-ethyl[1,1'-biphenyl]-4-yl)oxy]phenol	-	Plasmodium falciparum
5-(anilinomethyl)-2-[2-(dimethylamino)-4-(3-methylbutyl)phenoxy]phenol	-	Mycobacterium tuberculosis
5-(anilinomethyl)-2-[2-(dimethylamino)-4-(3-methylbutyl)phenoxy]phenol	-	Plasmodium falciparum
5-(anilinomethyl)-2-[2-(dimethylamino)-4-(propan-2-yl)phenoxy]phenol	-	Mycobacterium tuberculosis
5-(anilinomethyl)-2-[2-(dimethylamino)-4-(propan-2-yl)phenoxy]phenol	-	Plasmodium falciparum
5-(anilinomethyl)-2-[2-(methylamino)-4-(3-methylbutyl)phenoxy]phenol	-	Mycobacterium tuberculosis
5-(anilinomethyl)-2-[2-(methylamino)-4-(3-methylbutyl)phenoxy]phenol	-	Plasmodium falciparum
5-(anilinomethyl)-2-[2-(methylamino)-4-(propan-2-yl)phenoxy]phenol	-	Mycobacterium tuberculosis
5-(anilinomethyl)-2-[2-(methylamino)-4-(propan-2-yl)phenoxy]phenol	-	Plasmodium falciparum
5-(anilinomethyl)-2-[2-ethyl-4-(3-methylbutyl)phenoxy]phenol	-	Mycobacterium tuberculosis
5-(anilinomethyl)-2-[2-ethyl-4-(3-methylbutyl)phenoxy]phenol	-	Plasmodium falciparum
5-(anilinomethyl)-2-[2-ethyl-4-(propan-2-yl)phenoxy]phenol	-	Mycobacterium tuberculosis
5-(anilinomethyl)-2-[2-ethyl-4-(propan-2-yl)phenoxy]phenol	-	Plasmodium falciparum
5-(anilinomethyl)-2-{[3-(dimethylamino)[1,1'-biphenyl]-4-yl]oxy}phenol	-	Mycobacterium tuberculosis
5-(anilinomethyl)-2-{[3-(dimethylamino)[1,1'-biphenyl]-4-yl]oxy}phenol	-	Plasmodium falciparum
5-(anilinomethyl)-2-{[3-(methylamino)[1,1'-biphenyl]-4-yl]oxy}phenol	-	Mycobacterium tuberculosis
5-(anilinomethyl)-2-{[3-(methylamino)[1,1'-biphenyl]-4-yl]oxy}phenol	-	Plasmodium falciparum
5-(cyclohexylmethyl)-2-(2,4-dichlorophenoxy)phenol	-	Mycobacterium tuberculosis
5-(cyclohexylmethyl)-2-(2,4-dichlorophenoxy)phenol	-	Plasmodium falciparum
5-(cyclohexylmethyl)-2-[(3-ethyl[1,1'-biphenyl]-4-yl)oxy]phenol	-	Mycobacterium tuberculosis
5-(cyclohexylmethyl)-2-[(3-ethyl[1,1'-biphenyl]-4-yl)oxy]phenol	-	Plasmodium falciparum
5-(cyclohexylmethyl)-2-[2-(dimethylamino)-4-(3-methylbutyl)phenoxy]phenol	-	Mycobacterium tuberculosis
5-(cyclohexylmethyl)-2-[2-(dimethylamino)-4-(3-methylbutyl)phenoxy]phenol	-	Plasmodium falciparum
5-(cyclohexylmethyl)-2-[2-(dimethylamino)-4-(propan-2-yl)phenoxy]phenol	-	Mycobacterium tuberculosis
5-(cyclohexylmethyl)-2-[2-(dimethylamino)-4-(propan-2-yl)phenoxy]phenol	-	Plasmodium falciparum
5-(cyclohexylmethyl)-2-[2-(methylamino)-4-(3-methylbutyl)phenoxy]phenol	-	Mycobacterium tuberculosis
5-(cyclohexylmethyl)-2-[2-(methylamino)-4-(3-methylbutyl)phenoxy]phenol	-	Plasmodium falciparum
5-(cyclohexylmethyl)-2-[2-(methylamino)-4-(propan-2-yl)phenoxy]phenol	-	Mycobacterium tuberculosis
5-(cyclohexylmethyl)-2-[2-(methylamino)-4-(propan-2-yl)phenoxy]phenol	-	Plasmodium falciparum
5-(cyclohexylmethyl)-2-[2-ethyl-4-(3-methylbutyl)phenoxy]phenol	-	Mycobacterium tuberculosis
5-(cyclohexylmethyl)-2-[2-ethyl-4-(3-methylbutyl)phenoxy]phenol	-	Plasmodium falciparum
5-(cyclohexylmethyl)-2-[2-ethyl-4-(propan-2-yl)phenoxy]phenol	-	Mycobacterium tuberculosis
5-(cyclohexylmethyl)-2-[2-ethyl-4-(propan-2-yl)phenoxy]phenol	-	Plasmodium falciparum
5-(cyclohexylmethyl)-2-{[3-(dimethylamino)[1,1'-biphenyl]-4-yl]oxy}phenol	-	Mycobacterium tuberculosis
5-(cyclohexylmethyl)-2-{[3-(dimethylamino)[1,1'-biphenyl]-4-yl]oxy}phenol	-	Plasmodium falciparum
5-(cyclohexylmethyl)-2-{[3-(methylamino)[1,1'-biphenyl]-4-yl]oxy}phenol	-	Mycobacterium tuberculosis
5-(cyclohexylmethyl)-2-{[3-(methylamino)[1,1'-biphenyl]-4-yl]oxy}phenol	-	Plasmodium falciparum
5-({[(2,3-dihydro-1-benzofuran-6-yl)methyl]amino}methyl)-2-[2-methyl-4-(methylamino)phenoxy]phenol	-	Mycobacterium tuberculosis
5-({[(2,3-dihydro-1-benzofuran-6-yl)methyl]amino}methyl)-2-[2-methyl-4-(methylamino)phenoxy]phenol	-	Plasmodium falciparum
5-({[2-(4-chlorophenyl)ethyl]amino}methyl)-2-[2-(dimethylamino)-4-ethylphenoxy]phenol	-	Mycobacterium tuberculosis
5-({[2-(4-chlorophenyl)ethyl]amino}methyl)-2-[2-(dimethylamino)-4-ethylphenoxy]phenol	-	Plasmodium falciparum
5-({[2-(4-chlorophenyl)ethyl]amino}methyl)-2-[2-ethyl-4-(sulfanylmethyl)phenoxy]phenol	-	Mycobacterium tuberculosis
5-({[2-(4-chlorophenyl)ethyl]amino}methyl)-2-[2-ethyl-4-(sulfanylmethyl)phenoxy]phenol	-	Plasmodium falciparum
5-butyl-2-(2,4-dichlorophenoxy)phenol	-	Mycobacterium tuberculosis
5-butyl-2-(2,4-dichlorophenoxy)phenol	-	Plasmodium falciparum
5-chloro-2-(2,4-dichlorophenoxy)phenol	-	Mycobacterium tuberculosis
5-chloro-2-(2,4-dichlorophenoxy)phenol	-	Plasmodium falciparum
5-cyclohexyl-2-(2-hydrazinyl-4-propylphenoxy)phenol	-	Mycobacterium tuberculosis
5-cyclohexyl-2-(2-hydrazinyl-4-propylphenoxy)phenol	-	Plasmodium falciparum
5-[(benzylamino)methyl]-2-[2-(dimethylamino)-4-ethylphenoxy]phenol	-	Mycobacterium tuberculosis
5-[(benzylamino)methyl]-2-[2-(dimethylamino)-4-ethylphenoxy]phenol	-	Plasmodium falciparum
triclosan	-	Mycobacterium tuberculosis
triclosan	-	Plasmodium falciparum

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	-	-	-
Plasmodium falciparum	-	-	-

Synonyms

Synonyms	Comment	Organism
enoyl-ACP reductase	-	Mycobacterium tuberculosis
enoyl-ACP reductase	-	Plasmodium falciparum
enoyl-acyl carrier protein reductase	-	Mycobacterium tuberculosis
enoyl-acyl carrier protein reductase	-	Plasmodium falciparum
ENR	-	Plasmodium falciparum
InhA	-	Mycobacterium tuberculosis

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor
0.000021	-	pH and temperature not specified in the publication	Mycobacterium tuberculosis	2-(2,4-dichlorophenoxy)-5-(3-phenylpropyl)phenol
0.000029	-	pH and temperature not specified in the publication	Mycobacterium tuberculosis	2-(2,4-dichlorophenoxy)-5-[(pyridin-2-yl)methyl]phenol
0.000038	-	pH and temperature not specified in the publication	Plasmodium falciparum	2-(2,4-dichlorophenoxy)-5-[(4-fluorophenyl)methyl]phenol
0.000042	-	pH and temperature not specified in the publication	Mycobacterium tuberculosis	2-(2,4-dichlorophenoxy)-5-[(pyridin-3-yl)methyl]phenol
0.00005	-	pH and temperature not specified in the publication	Mycobacterium tuberculosis	2-(2,4-dichlorophenoxy)-5-(4-phenylbutyl)phenol
0.000051	-	pH and temperature not specified in the publication	Mycobacterium tuberculosis	2-(2,4-dichlorophenoxy)-5-(2-phenylethyl)phenol
0.000055	-	pH and temperature not specified in the publication	Mycobacterium tuberculosis	5-butyl-2-(2,4-dichlorophenoxy)phenol
0.000063	-	pH and temperature not specified in the publication	Mycobacterium tuberculosis	2-(2,4-dichlorophenoxy)-5-(3-methylbutyl)phenol
0.000071	-	pH and temperature not specified in the publication	Plasmodium falciparum	2-(2,4-dichlorophenoxy)-5-(2-phenylethyl)phenol
0.000073	-	pH and temperature not specified in the publication	Plasmodium falciparum	5-chloro-2-(2,4-dichlorophenoxy)phenol
0.000075	-	pH and temperature not specified in the publication	Mycobacterium tuberculosis	3-chloro-4-[2-hydroxy-4-[(pyridin-4-yl)methyl]phenoxy]benzonitrile
0.000076	-	pH and temperature not specified in the publication	Plasmodium falciparum	2-(2,4-dichlorophenoxy)-5-(3-phenylpropyl)phenol
0.000091	-	pH and temperature not specified in the publication	Mycobacterium tuberculosis	2-(2,4-dichlorophenoxy)-5-propylphenol
0.000096	-	pH and temperature not specified in the publication	Mycobacterium tuberculosis	2-(2,4-dichlorophenoxy)-5-(2-methylpropyl)phenol
0.00011	-	pH and temperature not specified in the publication	Plasmodium falciparum	2-(2,4-dichlorophenoxy)-5-ethylphenol
0.00011	-	pH and temperature not specified in the publication	Mycobacterium tuberculosis	5-(cyclohexylmethyl)-2-(2,4-dichlorophenoxy)phenol
0.00012	-	pH and temperature not specified in the publication	Mycobacterium tuberculosis	2-(2,4-dichlorophenoxy)-5-ethylphenol
0.00012	-	pH and temperature not specified in the publication	Plasmodium falciparum	2-(2,4-dichlorophenoxy)-5-(3-methylbutyl)phenol
0.00013	-	pH and temperature not specified in the publication	Mycobacterium tuberculosis	2-(2,4-dichlorophenoxy)-5-(2-methylbutyl)phenol
0.00018	-	pH and temperature not specified in the publication	Plasmodium falciparum	2-(2,4-dichlorophenoxy)-5-(2-methylpropyl)phenol
0.0002	-	pH and temperature not specified in the publication	Plasmodium falciparum	2-(2,4-dichlorophenoxy)-5-methylphenol
0.00021	-	pH and temperature not specified in the publication	Plasmodium falciparum	2-(2,4-dichlorophenoxy)-5-propylphenol
0.00023	-	pH and temperature not specified in the publication	Plasmodium falciparum	2-(2,4-dichlorophenoxy)-5-[(3-methylphenyl)methyl]phenol
0.00029	-	pH and temperature not specified in the publication	Plasmodium falciparum	2-(2,4-dichlorophenoxy)-5-(2-methylbutyl)phenol
0.00041	-	pH and temperature not specified in the publication	Plasmodium falciparum	3-chloro-4-[2-hydroxy-4-[(2-methylphenyl)methyl]phenoxy]benzonitrile
0.00044	-	pH and temperature not specified in the publication	Plasmodium falciparum	2-(2,4-dichlorophenoxy)-5-(4-phenylbutyl)phenol
0.00044	-	pH and temperature not specified in the publication	Plasmodium falciparum	2-(2,4-dichlorophenoxy)-5-[(2-methylphenyl)methyl]phenol
0.00048	-	pH and temperature not specified in the publication	Plasmodium falciparum	5-butyl-2-(2,4-dichlorophenoxy)phenol
0.00053	-	pH and temperature not specified in the publication	Plasmodium falciparum	5-(cyclohexylmethyl)-2-(2,4-dichlorophenoxy)phenol
0.00053	-	pH and temperature not specified in the publication	Plasmodium falciparum	3-chloro-4-[2-hydroxy-4-[(pyridin-4-yl)methyl]phenoxy]benzonitrile
0.00064	-	pH and temperature not specified in the publication	Plasmodium falciparum	2-(2,4-dichlorophenoxy)-5-[(pyridin-2-yl)methyl]phenol
0.0008	-	pH and temperature not specified in the publication	Mycobacterium tuberculosis	2-(2,4-dichlorophenoxy)-5-methylphenol
0.00084	-	pH and temperature not specified in the publication	Plasmodium falciparum	2-(2,4-dichlorophenoxy)-5-[(pyridin-3-yl)methyl]phenol
0.00087	-	pH and temperature not specified in the publication	Mycobacterium tuberculosis	2-(2,4-dichlorophenoxy)-5-[(3-methylphenyl)methyl]phenol
0.0011	-	pH and temperature not specified in the publication	Mycobacterium tuberculosis	5-chloro-2-(2,4-dichlorophenoxy)phenol
0.0013	-	pH and temperature not specified in the publication	Mycobacterium tuberculosis	2-(2,4-dichlorophenoxy)-5-[(2-methylphenyl)methyl]phenol
0.01	-	pH and temperature not specified in the publication	Mycobacterium tuberculosis	3-chloro-4-[2-hydroxy-4-[(2-methylphenyl)methyl]phenoxy]benzonitrile
0.01	-	pH and temperature not specified in the publication	Mycobacterium tuberculosis	2-(2,4-dichlorophenoxy)-5-[(4-fluorophenyl)methyl]phenol