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Literature summary for 1.3.1.9 extracted from

  • Yao, J.; Ericson, M.E.; Frank, M.W.; Rock, C.O.
    Enoyl-acyl carrier protein reductase I (FabI) is essential for the intracellular growth of Listeria monocytogenes (2016), Infect. Immun., 84, 3597-3607.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli JP1111 cells Listeria monocytogenes

Inhibitors

Inhibitors Comment Organism Structure
AFN-1252
-
Listeria monocytogenes

Localization

Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
28300
-
x * 28300, SDS-PAGE Listeria monocytogenes

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
trans-2-enoyl-[acyl-carrier protein] + NADH + H+ Listeria monocytogenes
-
acyl-[acyl-carrier protein] + NAD+
-
?

Organism

Organism UniProt Comment Textmining
Listeria monocytogenes
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trans-2-enoyl-[acyl-carrier protein] + NADH + H+
-
Listeria monocytogenes acyl-[acyl-carrier protein] + NAD+
-
?

Subunits

Subunits Comment Organism
? x * 28300, SDS-PAGE Listeria monocytogenes

Synonyms

Synonyms Comment Organism
enoyl-acyl carrier protein reductase I
-
Listeria monocytogenes
FabI
-
Listeria monocytogenes

Cofactor

Cofactor Comment Organism Structure
NADH
-
Listeria monocytogenes

General Information

General Information Comment Organism
metabolism the enzyme catalyzes the last step in each elongation cycle of type II bacterial fatty acid synthesis and is a key regulatory protein in bacterial fatty acid synthesis Listeria monocytogenes
physiological function the enzyme is essential for the intracellular growth of Listeria monocytogenes Listeria monocytogenes