Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21 cells | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-[4-(2,4-dichlorophenoxy)-3-hydroxyphenyl]-2-phenylethan-1-one | - |
Mycobacterium tuberculosis | |
1-[4-(2,4-dichlorophenoxy)-3-hydroxyphenyl]propan-1-one | - |
Mycobacterium tuberculosis | |
2-(2,4-dichlorophenoxy)-5-(hexylamino)phenol | 73% inhibition at 1 mM | Mycobacterium tuberculosis | |
2-(2,4-dichlorophenoxy)-5-[(1H-1,2,3-triazol-1-yl)methyl]phenol | 97% inhibition at 1 mM | Mycobacterium tuberculosis | |
2-(2,4-dichlorophenoxy)-5-[5-(trimethylsilyl)-1,2-oxazol-3-yl]phenol | complete inhibition at 1 mM | Mycobacterium tuberculosis | |
2-{4-[(4-benzyl-1H-1,2,3-triazol-1-yl)methyl]-2-chlorophenoxy}-5-chlorophenol | - |
Mycobacterium tuberculosis | |
2-{4-[(4-butyl-1H-1,2,3-triazol-1-yl)methyl]-2-chlorophenoxy}-5-chlorophenol | - |
Mycobacterium tuberculosis | |
2-{4-[(5-benzyl-1,2-oxazol-3-yl)methyl]-2-chlorophenoxy}-5-chlorophenol | - |
Mycobacterium tuberculosis | |
2-{4-[(5-butyl-1,2-oxazol-3-yl)methyl]-2-chlorophenoxy}-5-chlorophenol | - |
Mycobacterium tuberculosis | |
2-{4-[(benzylamino)methyl]-2-chlorophenoxy}-5-chlorophenol | - |
Mycobacterium tuberculosis | |
4-(2,4-dichlorophenoxy)-3-hydroxybenzonitrile | 97% inhibition at 1 mM | Mycobacterium tuberculosis | |
4-(2,4-dichlorophenoxy)-N-hexyl-3-hydroxybenzamide | - |
Mycobacterium tuberculosis | |
5-(5-benzyl-1,2-oxazol-3-yl)-2-(2,4-dichlorophenoxy)phenol | - |
Mycobacterium tuberculosis | |
5-(5-butyl-1,2-oxazol-3-yl)-2-(2,4-dichlorophenoxy)phenol | - |
Mycobacterium tuberculosis | |
5-(benzylamino)-2-(2,4-dichlorophenoxy)phenol | 25% inhibition at 1 mM | Mycobacterium tuberculosis | |
5-(cyclohexylamino)-2-(2,4-dichlorophenoxy)phenol | 12.5% inhibition at 1 mM | Mycobacterium tuberculosis | |
5-benzyl-N-{[3-chloro-4-(4-chloro-2-hydroxyphenoxy)phenyl]methyl}-1,2-oxazole-3-carboxamide | - |
Mycobacterium tuberculosis | |
5-chloro-2-{2-chloro-4-[(1H-1,2,3-triazol-1-yl)methyl]phenoxy}phenol | - |
Mycobacterium tuberculosis | |
5-chloro-2-{2-chloro-4-[(hexylamino)methyl]phenoxy}phenol | 38% inhibition at 1 mM | Mycobacterium tuberculosis | |
5-[(4-benzyl-1H-1,2,3-triazol-1-yl)methyl]-2-(2,4-dichlorophenoxy)phenol | - |
Mycobacterium tuberculosis | |
5-[(4-butyl-1H-1,2,3-triazol-1-yl)methyl]-2-(2,4-dichlorophenoxy)phenol | 98% inhibition at 1 mM | Mycobacterium tuberculosis | |
N,N-dibutyl-4-(2,4-dichlorophenoxy)-3-hydroxybenzamide | - |
Mycobacterium tuberculosis | |
N-benzyl-4-(2,4-dichlorophenoxy)-3-hydroxybenzamide | - |
Mycobacterium tuberculosis | |
N-{[3-chloro-4-(4-chloro-2-hydroxyphenoxy)phenyl]methyl}-2-(3-methyl-1,2-oxazol-5-yl)acetamide | - |
Mycobacterium tuberculosis | |
N-{[3-chloro-4-(4-chloro-2-hydroxyphenoxy)phenyl]methyl}-5-methyl-1,2-oxazole-3-carboxamide | - |
Mycobacterium tuberculosis | |
N-{[4-(2,4-dichlorophenoxy)-3-hydroxyphenyl]methyl}-5-methyl-1,2-oxazole-3-carboxamide | more than 80% inhibition at 1 mM | Mycobacterium tuberculosis | |
triclosan | 96% inhibition at 0.043 mM | Mycobacterium tuberculosis | |
[4-(2,4-dichlorophenoxy)-3-hydroxyphenyl](morpholin-4-yl)methanone | - |
Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
an acyl-[acyl-carrier protein] + NAD+ | Mycobacterium tuberculosis | - |
a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+ | - |
? | |
an acyl-[acyl-carrier protein] + NAD+ | Mycobacterium tuberculosis H37Rv | - |
a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Mycobacterium tuberculosis H37Rv | - |
- |
- |
Purification (Comment) | Organism |
---|---|
His-bind column chromatography and Sephadex G-25 gel filtration | Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
an acyl-[acyl-carrier protein] + NAD+ | - |
Mycobacterium tuberculosis | a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+ | - |
? | |
an acyl-[acyl-carrier protein] + NAD+ | - |
Mycobacterium tuberculosis H37Rv | a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+ | - |
? | |
crotonyl-CoA + NADH + H+ | - |
Mycobacterium tuberculosis | butyryl-CoA + NAD+ | - |
? | |
crotonyl-CoA + NADH + H+ | - |
Mycobacterium tuberculosis H37Rv | butyryl-CoA + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
enoyl-ACP reductase | - |
Mycobacterium tuberculosis |
InhA | - |
Mycobacterium tuberculosis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Mycobacterium tuberculosis |