Application | Comment | Organism |
---|---|---|
medicine | enoyl-acyl carrier protein reductase from Plasmodium falciparum is an important target for anti-malarial agents | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(2,4-dichlorophenoxy)-5-(2-phenylethyl)phenol | - |
Plasmodium falciparum | |
2-(4-[[(2,3-dihydro-1-benzofuran-6-ylmethyl)amino]methyl]-2-hydroxyphenoxy)-5-methylbenzonitrile | predicted inhibitor, based on in-silico screening | Plasmodium falciparum | |
2-[2-(dimethylamino)-4-sulfanylphenoxy]-5-[[(2-phenylethyl)amino]methyl]phenol | predicted inhibitor, based on in-silico screening | Plasmodium falciparum | |
4-[4-[(benzylamino)methyl]-2-hydroxyphenoxy]-3-chlorobenzonitrile | predicted inhibitor, based on in-silico screening | Plasmodium falciparum | |
5-([[2-(4-chlorophenyl)ethyl]amino]methyl)-2-[2-(dimethylamino)-4-ethylphenoxy]phenol | predicted inhibitor, based on in-silico screening | Plasmodium falciparum | |
5-([[2-(4-chlorophenyl)ethyl]amino]methyl)-2-[2-ethyl-4-(sulfanylmethyl)phenoxy]phenol | predicted inhibitor, based on in-silico screening | Plasmodium falciparum | |
5-cyclohexyl-2-[2-(methylamino)-4-propylphenoxy]phenol | predicted inhibitor, based on in-silico screening | Plasmodium falciparum | |
5-[(benzylamino)methyl]-2-[2-(dimethylamino)-4-ethylphenoxy]phenol | predicted inhibitor, based on in-silico screening | Plasmodium falciparum | |
5-[[(2,3-dihydro-1-benzofuran-6-ylmethyl)amino]methyl]-2-[2-methyl-4-(methylamino)phenoxy]phenol | predicted inhibitor, based on in-silico screening | Plasmodium falciparum | |
triclosan | - |
Plasmodium falciparum | |
[4-[4-([[2-(4-chlorophenyl)ethyl]amino]methyl)-2-hydroxyphenoxy]-3-(methylamino)phenyl]methanaminium | predicted inhibitor, based on in-silico screening | Plasmodium falciparum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
trans-2-enoyl-acyl-ACP + NADH + H+ | Plasmodium falciparum | - |
acyl-ACP + NAD+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trans-2-enoyl-acyl-ACP + NADH + H+ | - |
Plasmodium falciparum | acyl-ACP + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
enoyl-acyl carrier protein reductase | - |
Plasmodium falciparum |
pfENR | - |
Plasmodium falciparum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Plasmodium falciparum |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00005 | - |
triclosan | - |
Plasmodium falciparum |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000013 | - |
predicted IC50 | Plasmodium falciparum | 5-([[2-(4-chlorophenyl)ethyl]amino]methyl)-2-[2-(dimethylamino)-4-ethylphenoxy]phenol | |
0.000014 | - |
predicted IC50 | Plasmodium falciparum | 5-([[2-(4-chlorophenyl)ethyl]amino]methyl)-2-[2-ethyl-4-(sulfanylmethyl)phenoxy]phenol | |
0.000022 | - |
predicted IC50 | Plasmodium falciparum | 5-cyclohexyl-2-[2-(methylamino)-4-propylphenoxy]phenol | |
0.00003 | - |
predicted IC50 | Plasmodium falciparum | 5-[[(2,3-dihydro-1-benzofuran-6-ylmethyl)amino]methyl]-2-[2-methyl-4-(methylamino)phenoxy]phenol | |
0.000037 | - |
predicted IC50 | Plasmodium falciparum | 2-[2-(dimethylamino)-4-sulfanylphenoxy]-5-[[(2-phenylethyl)amino]methyl]phenol | |
0.00004 | - |
predicted IC50 | Plasmodium falciparum | [4-[4-([[2-(4-chlorophenyl)ethyl]amino]methyl)-2-hydroxyphenoxy]-3-(methylamino)phenyl]methanaminium | |
0.000042 | - |
predicted IC50 | Plasmodium falciparum | 5-[(benzylamino)methyl]-2-[2-(dimethylamino)-4-ethylphenoxy]phenol | |
0.00005 | - |
predicted IC50 | Plasmodium falciparum | 4-[4-[(benzylamino)methyl]-2-hydroxyphenoxy]-3-chlorobenzonitrile | |
0.000055 | - |
predicted IC50 | Plasmodium falciparum | 2-(4-[[(2,3-dihydro-1-benzofuran-6-ylmethyl)amino]methyl]-2-hydroxyphenoxy)-5-methylbenzonitrile | |
0.000073 | - |
- |
Plasmodium falciparum | triclosan | |
0.000076 | - |
- |
Plasmodium falciparum | 2-(2,4-dichlorophenoxy)-5-(2-phenylethyl)phenol |