Literature summary for 1.3.1.9 extracted from

Moir, D.T.
Identification of inhibitors of bacterial enoyl-acyl carrier protein reductase (2005), Curr. Drug Targets Infect. Disord., 5, 297-305.

Search for more literature for 1.3.1.9

Application

Application	Comment	Organism
medicine	antibacterial target	Staphylococcus aureus

Inhibitors

Inhibitors	Comment	Organism	Structure
5-chloro-2-(2,4-dichlorophenoxy)phenol	Triclosan	Staphylococcus aureus
5-chloro-2-phenoxyphenol	Triclosan derivative	Staphylococcus aureus
benzo-diazaborine	-	Staphylococcus aureus
gallocatechin gallate	-	Staphylococcus aureus
NB2001	Triclosan prodrug form	Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
acyl-[acyl-carrier protein] + NAD+	Staphylococcus aureus	-	trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Staphylococcus aureus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acyl-[acyl-carrier protein] + NAD+	-	Staphylococcus aureus	trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+	-	?
crotonyl-CoA + NADH + H+	activity assay	Staphylococcus aureus	butyryl-CoA + NAD+	-	?

Synonyms

Synonyms	Comment	Organism
enoyl-reductase	-	Staphylococcus aureus
enoyl-[acyl-carrier-protein] reductase	-	Staphylococcus aureus
FabI	-	Staphylococcus aureus
FabI-related enoyl-ACP reductase	-	Staphylococcus aureus

Cofactor

Cofactor	Comment	Organism	Structure
NADH	-	Staphylococcus aureus

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Release 2023.1 (January 2023)