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Literature summary for 1.3.1.9 extracted from
- Molecular dynamics simulation studies of the wild-type, I21V, and I16T mutants of isoniazid-resistant Mycobacterium tuberculosis enoyl reductase (InhA) in complex with NADH: toward the understanding of NADH-InhA different affinities (2005), Biophys. J., 89, 876-884.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | tuberculosis, TB, target of anti-tubercular agents | Mycobacterium tuberculosis |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| I16T | isoniazid resistant clinical mutant, in silico constructed | Mycobacterium tuberculosis |
| I21V | isoniazid resistant clinical mutant, in silico constructed | Mycobacterium tuberculosis |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.056 | - |
NADH | wild type enoyl-ACP reductase | Mycobacterium tuberculosis |  |
| 0.104 | - |
NADH | I21V mutant enoyl-ACP reductase | Mycobacterium tuberculosis | |
| 0.149 | - |
NADH | I16T mutantwild type enoyl-ACP reductase | Mycobacterium tuberculosis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-[acyl-carrier protein] + NAD+ | Mycobacterium tuberculosis | - |
trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-[acyl-carrier protein] + NAD+ | - |
Mycobacterium tuberculosis | trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| enoyl reductase | - |
Mycobacterium tuberculosis |
| enoyl-ACP reductase | - |
Mycobacterium tuberculosis |
| enoyl-[acyl-carrier-protein] reductase | - |
Mycobacterium tuberculosis |
| InhA | - |
Mycobacterium tuberculosis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | - |
Mycobacterium tuberculosis | |
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Release 2023.1 (January 2023)
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