Literature summary for 1.3.1.9 extracted from

Sivaraman, S.; Sullivan, T.J.; Johnson, F.; Novichenok, P.; Cui, G.; Simmerling, C.; Tonge, P.J.
Inhibition of the bacterial enoyl reductase FabI by triclosan: a structure-reactivity analysis of FabI inhibition by triclosan analogues (2004), J. Med. Chem., 47, 509-518.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-(2-hydroxybenzyl)-phenol	uncompetitive inhibition	Escherichia coli
2-(2-hydroxyphenyl)-phenol	uncompetitive inhibition	Escherichia coli
2-phenoxyphenol	noncompetitive inhibition	Escherichia coli
4-(4-hydroxyphenyl)-phenol	uncompetitive inhibition	Escherichia coli
5-chloro-2-(2,4-dichloro-phenoxy)phenol	trivial name triclosan, slow, tight-binding inhibitor	Escherichia coli
5-chloro-2-phenoxyphenol	slow binding inhibitor	Escherichia coli
5-fluoro-2-phenoxyphenol	slow binding inhibitor	Escherichia coli
5-methyl-2-phenoxyphenol	slow binding inhibitor	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
trans-2-dodecenoyl-CoA + NADH	-	Escherichia coli	dodecanoyl-CoA + NAD+	-	?

Synonyms

Synonyms	Comment	Organism
FabI	-	Escherichia coli

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Release 2023.1 (January 2023)