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Literature summary for 1.3.1.86 extracted from

  • Li, C.; Florova, G.; Akopiants, K.; Reynolds, K.A.
    Crotonyl-coenzyme A reductase provides methylmalonyl-CoA precursors for monensin biosynthesis by Streptomyces cinnamonensis in an oil-based extended fermentation (2004), Microbiology, 150, 3463-3472.
    View publication on PubMed
Search for more literature for 1.3.1.86

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Streptomyces cinnamonensis strain L1 Streptomyces collinus

Organism

Organism UniProt Comment Textmining
Streptomyces collinus
-
-
-
Streptomyces virginiae
-
 strain C730.1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
crotonyl-CoA + NADPH + H+
-
 Streptomyces virginiae butyryl-CoA + NADP+
-
 ?
crotonyl-CoA + NADPH + H+
-
 Streptomyces collinus butyryl-CoA + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
CCR
-
 Streptomyces virginiae
CCR
-
 Streptomyces collinus
crotonyl-coenzyme A reductase
-
 Streptomyces virginiae
crotonyl-coenzyme A reductase
-
 Streptomyces collinus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Streptomyces virginiae
NADPH
-
 Streptomyces collinus

General Information

General Information Comment Organism
malfunction loss of ccr leads to lower levels of the monensin precursor methymalonyl-CoA, relative to coenzyme A Streptomyces virginiae
malfunction loss of ccr leads to lower levels of the monensin precursor methymalonyl-CoA, relative to coenzyme A Streptomyces collinus
physiological function CCR plays a significant role in providing methylmalonyl-CoA for monensin biosynthesis in oil-based 10-day fermentations of Streptomyces cinnamonensis Streptomyces virginiae
physiological function CCR plays a significant role in providing methylmalonyl-CoA for monensin biosynthesis in oil-based 10-day fermentations of Streptomyces cinnamonensis Streptomyces collinus