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Literature summary for 1.3.1.78 extracted from

  • Schenck, C.A.; Chen, S.; Siehl, D.L.; Maeda, H.A.
    Non-plastidic, tyrosine-insensitive prephenate dehydrogenases from legumes (2015), Nat. Chem. Biol., 11, 52-57 .
    View publication on PubMed
Search for more literature for 1.3.1.78

Cloned(Commentary)

Cloned (Comment) Organism
gene ADH1, phylogenetic analysis Arabidopsis thaliana
gene ADH2, phylogenetic analysis Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
L-tyrosine strong inhibition; strong inhibition Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
chloroplast
-
 Arabidopsis thaliana 9507
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arogenate + NADP+ Arabidopsis thaliana
-
 L-tyrosine + NADPH + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q944B6
-
-
Arabidopsis thaliana Q9LMR3
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arogenate + NADP+
-
 Arabidopsis thaliana L-tyrosine + NADPH + CO2
-
 ?

Synonyms

Synonyms Comment Organism
ADH1
-
 Arabidopsis thaliana
ADH2
-
 Arabidopsis thaliana
arogenate dehydrogenase
-
 Arabidopsis thaliana
TyrAa
-
 Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
evolution prephenate dehydrogenases (TyrAps, also known as PDHs) from two legumes, Glycine max (soybean) and Medicago truncatula, are phylogenetically distinct from canonical plant ADH enzymes, prefer prephenate to arogenate substrate, localize outside of the plastids and are not inhibited by L-Tyr. Diversification of primary metabolic Tyr pathway via an alternative cytosolic PDH pathway in plants, phylogenetic and biochemical differentiation of ADHs and PDHs Arabidopsis thaliana
metabolism in plants, L-Tyr is synthe­sized in the plastids via the arogenate dehydrogenase pathway, in which prephenate is first converted to arogenate by prephenate aminotransferase, EC 2.6.1.7, and then to L-Tyr by enzyme ADH Arabidopsis thaliana