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Literature summary for 1.3.1.78 extracted from

  • Connelly, J.A.; Conn, E.E.
    Tyrosine biosynthesis in Sorghum bicolor: isolation and regulatory properties of arogenate dehydrogenase (1986), Z. Naturforsch. C, 41, 69-78.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
L-tyrosine
-
Sorghum bicolor
prephenate no inhibition Sorghum bicolor

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.011
-
NADP+
-
Sorghum bicolor
0.34
-
L-arogenate
-
Sorghum bicolor

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arogenate + NAD+ Sorghum bicolor important enzyme in regulation of tyrosine biosynthesis L-tyrosine + NADH + CO2
-
?
L-arogenate + NAD+ Sorghum bicolor i.e. 3-(1-carboxy-4-hydroxycyclohexa-2,5-dien-1-yl)-L-alanine, final biosynthetic step to tyrosine L-tyrosine + NADH + CO2
-
?

Organism

Organism UniProt Comment Textmining
Sorghum bicolor
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Sorghum bicolor

Source Tissue

Source Tissue Comment Organism Textmining
seedling
-
Sorghum bicolor
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.43
-
-
Sorghum bicolor

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arogenate + NAD(P)+
-
Sorghum bicolor L-tyrosine + NAD(P)H + CO2
-
?
L-arogenate + NAD+ important enzyme in regulation of tyrosine biosynthesis Sorghum bicolor L-tyrosine + NADH + CO2
-
?
L-arogenate + NAD+ i.e. 3-(1-carboxy-4-hydroxycyclohexa-2,5-dien-1-yl)-L-alanine, final biosynthetic step to tyrosine Sorghum bicolor L-tyrosine + NADH + CO2
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+ not Sorghum bicolor
NADP+
-
Sorghum bicolor

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.06
-
L-tyrosine
-
Sorghum bicolor