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Literature summary for 1.3.1.76 extracted from

  • Fazzio, T.G.; Roth, J.R.
    Evidence that the CysG protein catalyzes the first reaction specific to B12 synthesis in Salmonella typhimurium, insertion of cobalt (1996), J. Bacteriol., 178, 6952-6959.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.1.76

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ enzyme catalyzes cobalt insertion leading to B12 synthesis Salmonella enterica subsp. enterica serovar Typhimurium
Fe2+ enzyme catalyzes iron insertion leading to siroheme synthesis Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
precorrin-2 + NAD+ Salmonella enterica subsp. enterica serovar Typhimurium precorrin-2 is the precursor of both siroheme and B12, first reaction specific to B12 synthesis, second of three steps leading to formation of siroheme from uroporphyrinogen III sirohydrochlorin + NADH + H+
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Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
precorrin-2 + NAD+
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 Salmonella enterica subsp. enterica serovar Typhimurium sirohydrochlorin + NADH + H+
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 ?
precorrin-2 + NAD+ precorrin-2 is the precursor of both siroheme and B12, first reaction specific to B12 synthesis, second of three steps leading to formation of siroheme from uroporphyrinogen III Salmonella enterica subsp. enterica serovar Typhimurium sirohydrochlorin + NADH + H+
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 ?

Synonyms

Synonyms Comment Organism
CysG
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 Salmonella enterica subsp. enterica serovar Typhimurium
CysG enzyme
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 Salmonella enterica subsp. enterica serovar Typhimurium