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Literature summary for 1.3.1.74 extracted from

  • Dick, R.A.; Kwak, M.K.; Sutter, T.R.; Kensler, T.W.
    Antioxidative function and substrate specificity of NAD(P)H-dependent alkenal/one oxidoreductase. A new role for leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase (2001), J. Biol. Chem., 276, 40803-40810.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
cyclovalone
-
Rattus norvegicus
progesterone
-
Rattus norvegicus
quercetin
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.001
-
15-oxoprostaglandin E1 30°C Rattus norvegicus
0.11
-
ethyl vinyl ketone 30°C Rattus norvegicus
0.12
-
4-hydroxy-2-nonenal 30°C Rattus norvegicus
0.15
-
acrolein 30°C Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
n-alkanal + NAD(P)+ Rattus norvegicus role in detoxication alk-2-enal + NAD(P)H
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Storage Stability

Storage Stability Organism
-80°C, no loss of activity for 8 months Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
15-oxoprostaglandin E1 + NAD(P)H
-
Rattus norvegicus ? + NAD(P)+
-
?
4-hydroxy-(2E)-nonenal + NAD(P)H
-
Rattus norvegicus 4-hydroxynonylaldehyde + NAD(P)+
-
?
benzylidine acetone + NAD(P)H reduction of alpha,beta-double bond Rattus norvegicus ? + NAD(P)+
-
?
ethyl vinyl ketone + NAD(P)H
-
Rattus norvegicus diethylketone + NAD(P)+
-
?
methyl vinyl ketone + NAD(P)H
-
Rattus norvegicus dimethylketone + NAD(P)+
-
?
additional information reduction of the alpha,beta-carbon-carbon double bond to a single bond, broad substrate specificity Rattus norvegicus ?
-
?
n-alkanal + NAD(P)+
-
Rattus norvegicus alk-2-enal + NAD(P)H
-
?
n-alkanal + NAD(P)+ role in detoxication Rattus norvegicus alk-2-enal + NAD(P)H
-
?
propenal + NAD(P)H synonym: acrolein Rattus norvegicus propanal + NAD(P)+
-
?
trans,trans-2,4-alkadienal + NAD(P)H
-
Rattus norvegicus ? + NAD(P)+
-
?
trans-2-alkenal + NAD(P)H
-
Rattus norvegicus alkanal + NAD(P)+
-
?
trans-4-hydroxy-2-alkenal + NAD(P)H
-
Rattus norvegicus 4-hydroxyalkanal + NAD(P)+
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Rattus norvegicus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.67
-
acrolein 30°C Rattus norvegicus
40
-
15-oxoprostaglandin E1 30°C Rattus norvegicus
66.7
-
4-hydroxy-2-nonenal 30°C Rattus norvegicus
160
-
ethyl vinyl ketone 30°C Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Rattus norvegicus