Cloned (Comment) | Organism |
---|---|
expressed in CHO cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
24(S),25-epoxycholesterol | incubation with 24(S),25-epoxycholesterol results in accumulation of desmosterol at the expense of cholesterol, consistent with inhibition of DHCR24 activity | Cricetulus griseus | |
24(S),25-epoxycholesterol | incubation with 24(S),25-epoxycholesterol results in accumulation of desmosterol at the expense of cholesterol, consistent with inhibition of DHCR24 activity | Homo sapiens | |
Triparanol | - |
Cricetulus griseus | |
Triparanol | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cricetulus griseus | - |
- |
- |
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CHO cell | - |
Cricetulus griseus | - |
Hep-G2 cell | - |
Homo sapiens | - |
neuronal cell line | BE(2)C cell line | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
3beta-hydroxysterol DELTA24-reductase | - |
Cricetulus griseus |
3beta-hydroxysterol DELTA24-reductase | - |
Homo sapiens |
DHCR24 | - |
Cricetulus griseus |
DHCR24 | - |
Homo sapiens |
seladin-1 | - |
Cricetulus griseus |
seladin-1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | DHCR24 overexpressed in CHO cells show that untreated CHO-DHCR24 cells have a higher cholesterol to desmosterol ratio. In the CHO-DHCR24 cells, more 24(S),25-epoxycholesterol is required to attain the same cholesterol to desmosterol ratio as in CHO cells expressing an empty vector. Thus, with DHCR24 overexpression, the effect of 24(S),25-epoxycholesterol on the cholesterol to desmosterol ratio is blunted | Homo sapiens |